文献类型：期刊文献

英文题名：Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

作者：Ding, Yingying[1,2];Botchway, Benson O. A.[3,4];Zhang, Yong[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China;[2]Hangzhou Normal Univ, Affiliated Hosp, Dept Clin Med, Hangzhou, Peoples R China;[3]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[4]Bupa Cromwell Hosp, London, England

年份：2023

卷号：14

期号：12

起止页码：5537

外文期刊名：FOOD & FUNCTION

收录：SCI-EXPANDED(收录号：WOS:001001909400001)、、EI(收录号：20232514271102)、Scopus(收录号：2-s2.0-85162140818)、WOS

语种：英文

外文关键词：Chemical activation - Neurodegenerative diseases - Signaling

外文摘要：Parkinson's disease (PD) is the second most common neurodegenerative disease (ND). It is the progressive loss of neurons and abnormal accumulation of alpha-synuclein due to multiple etiologies. Currently, supportive treatment is the only intervention for PD. However, supportive treatment has serious side effects. Ginsenosides, a group of sterol compounds, are the main active ingredients of ginseng. They have a potential role in NDs and psychosis. The brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) signaling pathway is closely related to the growth, survival and differentiation of neurons. Ginsenosides exert a neuroprotective role in NDs and psychosis by upregulating BDNF and activating the BDNF/TrkB signaling pathway. Herein, we analyzed the relationship between ginsenosides, BDNF, the BDNF/TrkB signaling pathway, NDs, and psychosis. We hypothesize that ginsenosides may protect neurons to improve PD by activating the BDNF/TrkB pathway.