文献类型：期刊文献

英文题名：Zn2+ Doped Ultrasmall Prussian Blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance

作者：Shou, Pingbo[1];Yu, Zhangsen[1];Wu, Yiting[1];Feng, Qiang[1];Zhou, Bangyi[1];Xing, Jie[2,3];Liu, Chuang[2,3];Tu, Jinqing[1];Akakuru, Ozioma Udochukwu[2,3];Ye, Zhiqiu[1];Zhang, Xiaojuan[1];Lu, Zhenbo[1];Zhang, Luyun[2,3];Wu, Aiguo[2,3]

机构：[1]Shaoxing Univ, Nano Biomed Grp, Ctr Sci Res, Sch Med, Shaoxing 312000, Peoples R China;[2]Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, Ningbo 315201, Zhejiang, Peoples R China;[3]Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China

年份：2020

卷号：9

期号：1

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：SCI-EXPANDED(收录号：WOS:000497218100001)、、WOS

基金：This work was financially supported by the projects of National Key R&D Program of China (2018YFC0910601), Science and Technology Plan in Shaoxing City (2018C10011), National Natural Science Foundation of China (31971292), National College Students Innovation and Entrepreneurship Training Program, China (201710349011), College Students' Science and Technology Innovation Project of Zhejiang Province (2019R432024 and 2017R428021), Educational Commission of Zhejiang Province, China (No. Y201839726), University Laboratory Work Research Project of Zhejiang Province (YB201722), Scientific Research Start-up Project of Shaoxing University (20185024), the Hundred Talents Program of Chinese Academy of Sciences (2010-735), and the Science & Technology Bureau of Ningbo City (2015B11002 and 2017C110022).

语种：英文

外文关键词：cancer theranostics; magnetic resonance imaging; photothermal therapy; Zn2+ doped ultrasmall Prussian blue

外文摘要：Prussian blue nanoprobes are widely studied and applied in tumor photothermal therapy (PTT) and magnetic resonance imaging (MRI), due to their low toxicity and excellent in vivo performance. However, the sizes of hitherto reported Prussian blue nanoprobes are generally larger than 50 nm, which greatly influence cell phagocytosis, in vivo circulation, and biodistribution. In this work, a novel method of doping zinc ions is used to control the size of Prussian blue nanoprobes. Consequently, the performances of the nanoprobes in PTT and MRI are both significantly improved. The results show that the minimum size of Prussian blue nanoprobes achieved by doping 10% zinc ions (abbreviated as SPBZn(10%)) is 3.8 +/- 0.90 nm, and the maximum specific absorption coefficient, photothermal conversion efficiency, and longitudinal relaxation rates are 1.78 L g(-1) cm(-1), 47.33%, and 18.40 mm(-1) s(-1), respectively. In addition, the SPBZn(10%) nanoprobes provide excellent PTT efficacy on 4T1 tumor cells (killing rate: 90.3%) and breast cancer model (tumor inhibition rate: 69.4%). Toxicological experiment results show that the SPBZn(n%) nanoprobes exhibit no obvious in vitro cytotoxicity and they can be used safely in mice at doses below 100 mg kg(-1). Therefore, SPBZn(10%) nanoprobes can potentially be used for effective cancer theranostics.