文献类型：期刊文献

英文题名：Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

作者：Liang, Wenqing[1];Chen, Xiaozhen[2];Zhang, Songou[2];Fang, Jian[2];Chen, Meikai[3];Xu, Yifan[3];Chen, Xuerong[3]

机构：[1]Zhejiang Chinese Med Univ, Zhoushan Hosp Tradit Chinese Med, Dept Orthopaed, 355 Xingiao Rd, Zhoushan 316000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Coll Med, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Affiliated Hosp 1, Shaoxing Peoples Hosp, Dept Orthopaed, Shaoxing 312000, Zhejiang, Peoples R China

年份：2021

卷号：26

期号：1

外文期刊名：CELLULAR & MOLECULAR BIOLOGY LETTERS

收录：SCI-EXPANDED(收录号：WOS:000609175200001)、、Scopus(收录号：2-s2.0-85099677706)、WOS

基金：This study was supported by the Nature Science Foundation of Zhejiang Province (LY18H060013 to WQL) and the Fundamental Research Program of Public Good in Zhejiang Province (LGF18H060006 to FJ, LGF20H060010 to XRC).

语种：英文

外文关键词：Angiogenesis; Cancer-associated fibroblasts; Immunosuppression; Metastasis; Mesenchymal stem cells

外文摘要：Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial-mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.