文献类型：期刊文献

英文题名：Photoinduced decarboxylative radical cascade alkylation/cyclization of benzimidazole derivatives with an aliphatic carboxylic acid via ligand-to-iron charge transfer

作者：Xu, Yan[1]; Wang, ChenJing[1]; Lv, Chun[1]; Wang, Jianjie[1]; Zhang, Qian[1]; Wang, Jiayang[2]; Shen, Run-Pu[4]; Sun, Bin[1,3]; Jin, Can[1,3]

机构：[1] College of Pharmaceutical Sciences, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China; [2] School of Life Sciences, HuZhou University, Zhejiang, HuZhou, China; [3] Key Laboratory for Green Pharmaceutical Technologies and Related Equipment, Ministry of Education, China; [4] Zhejiang Engineering Research Centre of Fat-soluble Vitamin, Shaoxing University, Shaoxing, 312000, China

年份：2024

卷号：48

期号：33

起止页码：14684

外文期刊名：New Journal of Chemistry

收录：EI(收录号：20243316868808)、Scopus(收录号：2-s2.0-85200898023)

语种：英文

外文关键词：Carboxylation - Carboxylic acids - Charge transfer - Chelation - Iron - Ligands

外文摘要：The photoinduced decarboxylative radical cascade alkylation/cyclization strategy of diverse benzimidazoles containing unactivated alkene moieties towards the synthesis of polycyclic benzimidazoles via ligand-to-metal-charge-transfer (LMCT) has been developed. Specifically, the reaction initiates the decarboxylation of alkyl carboxylic acids through light-induced charge transfer from the ligand to iron, resulting in the formation of alkyl radical centers. Moreover, the protocol has prominent features, such as a broad substrate scope, high regioselectivity, mild reaction conditions, operational simplicity and readily available air acting as the sole oxidant. ? 2024 The Royal Society of Chemistry.