文献类型：期刊文献

英文题名：Facile Synthesis of Multifunctional Magnetoplasmonic Au-MnO Hybrid Nanocomposites for Cancer Theranostics

作者：Tian, Cong[1,2];Tang, Zhe[1,2];Hou, Yike[1,2];Mushtaq, Asim[1,2];Naz, Shafaq[3];Yu, Zhangsen[4];Farheen, Jabeen[1,2];Iqbal, Muhammad Zubair[1,2];Kong, Xiangdong[1,2]

机构：[1]Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Inst Smart Biomed Mat, Hangzhou 310018, Peoples R China;[2]Zhejiang Mauritius Joint Res Ctr Biomat & Tissue, Hangzhou 310018, Peoples R China;[3]Univ Gujrat, Dept Math, Hafiz Hayat Campus, Gujrat 50700, Pakistan;[4]Shaoxing Univ, Med Sci Res Ctr, Sch Med, Lab Nanomed, Shaoxing 312000, Peoples R China

年份：2022

卷号：12

期号：8

外文期刊名：NANOMATERIALS

收录：SCI-EXPANDED(收录号：WOS:000785538600001)、、Scopus(收录号：2-s2.0-85128445073)、WOS

基金：The authors acknowledge the support of the National Natural Science Foundation of China (81950410638, 51672250), Key Research and Development Program of Zhejiang Province (2021C01180), Zhejiang Natural Science Foundation of China (LQ19E020010), and Zhejiang In-ternational Science and Technology Cooperation Project (2019C04020).

语种：英文

外文关键词：plasmonic nanoparticles; magnetic nanocomposites; TMagnetic contrast agents; photothermal therapy; cancer theranostics

外文摘要：Significant attention is paid to the design of magnetoplasmonic nanohybrids, which exploit synergistic properties for biomedical applications. Here, a facile method was employed to prepare plasmonic magnetic Au-MnO heterostructured hybrid nanoparticles for imaging-guided photothermal therapy of cancers in vitro, with the view to reducing the serious drawbacks of chemotherapy and gadolinium-based contrast agents. The biocompatibility of the prepared Au-MnO nanocomposites was further enhanced by Food and Drug Administration (FDA)-approved triblock copolymers Pluronic (R) F-127 and chitosan oligosaccharide (COS), with complementary support to enhance the absorption in the near-infrared (NIR) region. In addition, synthesized COS-PF127@Au-MnO nanocomposites exhibited promising contrast enhancement in T-1 MR imaging with a good r(1) relaxivity value (1.2 mM(-1) s(-1)), demonstrating a capable substitute to Gd-based toxic contrast agents. In addition, prepared COS-PF127@Au-MnO hybrid nanoparticles (HNPs) produced sufficient heat (62 degrees C at 200 mu g/mL) to ablate cancerous cells upon 808 nm laser irradiation, inducing cell toxicity, and apoptosis. The promising diagnostic and photothermal therapeutic performance demonstrated the appropriateness of the COS-PF127@Au-MnO HNPs as a potential theranostic agent.