文献类型：期刊文献

英文题名：Proteomic and functional analysis of proteins related to embryonic development of decidua in patients with recurrent pregnancy loss

作者：Xiong, Yi-Meng[1,2,3,4,5];Pan, Hai-Tao[2,4,5,6,7];Ding, Hai-Gang[6,7];He, Yao[6,7];Zhang, Juan[6,7];Zhang, Feng[6,7];Yu, Bin[6,7];Zhang, Tao[6,7];Huang, He-Feng[1,2,4,5]

机构：[1]Zhejiang Univ, Minist Educ, Key Lab Reprod Genet, Hangzhou 310058, Peoples R China;[2]Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai, Peoples R China;[3]Zhejiang Univ, Sch Med, Dept Pathol & Pathophysiol, Hangzhou, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Med, Inst Embryo Fetal Original Adult Dis, Shanghai, Peoples R China;[5]Shanghai Key Lab Embryo Original Dis, Shanghai, Peoples R China;[6]Shaoxing Matern & Child Hlth Care Hosp, Shaoxing 312000, Peoples R China;[7]Shaoxing Univ, Obstet & Gynecol Hosp, Shaoxing, Peoples R China

年份：2021

卷号：105

期号：5

起止页码：1246

外文期刊名：BIOLOGY OF REPRODUCTION

收录：SCI-EXPANDED(收录号：WOS:000743456300017)、、Scopus(收录号：2-s2.0-85121961338)、WOS

基金：This work was supported by the National Natural Science Foundation of China (82071729), the Zhejiang Provincial Natural Science Foundation of China (LY19H040002), the Science Technology Department of Zhejiang Province, China (LGF21H040003), the Health Commission of Zhejiang Province, China (2021KY1154, 2021KY1157, 2019KY229, 2019KY230), and the Science Technology Department of Shaoxing, China (2020A13032, 2020A13037, 2018C30042, 2018C30043, 2018C30044, 2018C30048).

语种：英文

外文关键词：recurrent pregnancy loss; TMT; decidua; IPA; embryonic development

外文摘要：Recurrent pregnancy loss (RPL) is defined as the loss of two or more consecutive pregnancies before the 20 weeks of gestation. RPL affects about 1-2% of couples trying to conceive; however, the mechanisms leading to this complication are largely unknown. Our previous studies using comparative proteomics identified 314 differentially expressed proteins (DEPs) in the placental villous. In this study, we identified 5479 proteins from a total of 34 157 peptides in decidua of patients with early RPL (data are available via ProteomeXchange with identifier PXD023849). Further analysis identified 311 DEPs in the decidua tissue; and 159 proteins were highly expressed, whereas 152 proteins were lowly expressed. These 311 proteins were further analyzed by using Ingenuity Pathway Analysis. The results suggested that 50 DEPs played important roles in the embryonic development. Upstream analysis of these DEPs revealed that angiotensinogen was the most important upstream regulator. Furthermore, protein-protein interaction analysis of the embryonic development DEPs from the placental villous and decidua was performed in the STRING database. This study identified several proteins specifically associated with embryonic development in decidua of patients with early RPL. Therefore, these results provide new insights into potential biological mechanisms, which may ultimately inform RPL. Summary sentence Proteomic and functional analysis of decidua in patients with recurrent pregnancy loss.