文献类型：期刊文献

英文题名：Alginate Oligosaccharide DP5 Exhibits Antitumor Effects in Osteosarcoma Patients following Surgery

作者：Chen, Jiayu[1];Hu, Yu[2];Zhang, Lirong[2];Wang, Yingjian[3];Wang, Shichao[3];Zhang, Yanzi[4];Guo, Haiyan[5];Ji, Degang[6];Wang, Yingtao[7]

机构：[1]Shaoxing Univ, Sch Med, Dept Basic Med, Shaoxing, Peoples R China;[2]Jilin Univ, Dept Pathol, China Japan Union Hosp, Changchun, Jilin, Peoples R China;[3]Jilin Univ, Dept Gynecol & Obstet, China Japan Union Hosp, Changchun, Jilin, Peoples R China;[4]Wenzhou Med Coll, Wenzhou, Peoples R China;[5]Tumor Hosp Jilin Prov, Dept Pathol, Changchun, Jilin, Peoples R China;[6]Jilin Univ, China Japan Union Hosp, Dept Hepatobiliary Pancreat Surg, Changchun, Jilin, Peoples R China;[7]Jilin Univ, China Japan Union Hosp, Dept Pharm, Changchun, Jilin, Peoples R China

年份：2017

卷号：8

期号：SEP

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：SCI-EXPANDED(收录号：WOS:000410366700001)、、Scopus(收录号：2-s2.0-85029675147)、WOS

基金：We are very grateful to two reviewers for their critical and strategic comments, which have significantly improved the quality of present paper. The project is supported by Jilin science and technology development program (No. 20140414018GH).

语种：英文

外文关键词：alginate oligosaccharide; local recurrence; osteosarcoma; tumor volume; antioxidant; anti-inflammatory

外文摘要：Osteosarcoma is a malignant musculoskeletal tumor that has high-rate morbidity and mortality worldwide. Alginate oligosaccharide (AOS), a natural product, has antitumor activities and may have therapeutic effects in osteosarcoma, the molecular mechanisms of which remain unclear. AOS was prepared from alginate sodium using alginate lyase. The fractions of AOS were further isolated by size-exclusion chromatography and verified by electrospray ionization mass spectrometry (ESI-MS). Osteosarcoma patients were enrolled in the study and assigned into two groups: AOS (AG, oral administration of 10-mg AOS daily) and control groups (CG, placebo). Preoperative and postoperative clinical data were investigated and analyzed. Four different degrees of polymerizations (DPs) were isolated and denominated as DP2, DP3, DP4, and DP5. Among these polymers, only DP5 showed antitumor functions on osteosarcoma cells. Before surgery and the outcome of primary end point after surgery, no significant differences were observed for clinical data and tumor size between the AG and CG groups (P > 0.05). After 2-year therapy, the mean tumor volume was 214.6 +/- 145.7 c.c. in AG and 467.2 +/- 225.3 c.c in CG (P < 0.01). The rate of local recurrence was 44.9 and 68.7% in AG and CG, respectively (P < 0.01). AOS treatment resulted in the increase in serum levels of SOD, GSH, HDL-C, and reduction in the levels of interleukin-1 (IL-1) beta and IL-6; the ratios of AST/ALT; and triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol LDL-C, and malondialdehyde (MDA) (P < 0.05). AOS reduces osteosarcoma progression, which is associated with improvement in antioxidant and anti-inflammatory capacities of patients, and may be used as a potential drug for osteosarcoma therapy.