文献类型：期刊文献

英文题名：Synthesis and antiproliferative activity of multisubstituted N-fused heterocycles against the Hep-G2 cancer cell line

作者：Shen, Yong-Miao[1];Lv, Peng-Cheng[2];Zhang, Ming-Zhu[1];Xiao, Hui-Quan[1];Deng, Li-Ping[1];Zhu, Hai-Liang[2];Qi, Chen-Ze[1]

机构：[1]Shaoxing Univ, Inst Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

年份：2011

卷号：142

期号：5

起止页码：521

外文期刊名：MONATSHEFTE FUR CHEMIE

收录：SCI-EXPANDED(收录号：WOS:000290227600012)、、Scopus(收录号：2-s2.0-79955904351)、WOS

基金：The work was supported by the National Natural Science Foundation of China (NSFC, 30772627) and Zhejiang Provincial Natural Science Foundation (Y4080395, Y4080481).

语种：英文

外文关键词：N-fused heterocycles; Antiproliferative activity; Structure-activity relationship; Hep-G2 cell line

外文摘要：Pyrrolo[1,2-a]imidazole and pyrrolo[2,1-b]thiazole derivatives were synthesized in a one-pot procedure by [3 + 2] cycloaddition reactions of the corresponding imidazolium ylides and thiazolium ylides with an alkene followed by oxidative aromatization of the primary cycloadducts under the action of the mild oxidant tetrakispyridinecobalt(II) dichromate. Antiproliferative activity of 14 new bicyclic N-fused heterocycles against the human hepatocellular liver carcinoma (Hep-G2) cell line were examined by the MTT method. Some of the compounds showed favorable antiproliferative activity, especially compound 3i displayed potent antiproliferative activities with an IC(50) value of 0.36 mu g/cm(3).