文献类型：期刊文献

英文题名：Inhibition of NF-kappa B Signaling Pathway by Resveratrol Improves Spinal Cord Injury

作者：Xu, Luyao[1];Botchway, Benson O. A.[2];Zhang, Songou[1];Zhou, Jingying[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Zhejiang, Peoples R China

年份：2018

卷号：12

外文期刊名：FRONTIERS IN NEUROSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000446353200001)、、Scopus(收录号：2-s2.0-85055246174)、WOS

基金：The Natural Science Foundation of Zhejiang Province (No. LY15H170001) and the Public Technology Applied Research Projects Foundation of Shaoxing City (No. 2015B70040) supported this work.

语种：英文

外文关键词：spinal cord injury; resveratrol; NF-kappa B signaling pathway; inflammation; apoptosis

外文摘要：Spinal cord injury (SCI) can have a significant impact on an individual's life. Herein, we discuss how resveratrol improves SCI by inhibiting nuclear factor kappa-lightchain-enhancer of activated B cells (NF-kappa B) signaling pathway. Evidences show resveratrol suppresses NF-kappa B signaling pathway to exert its beneficial effects on various diseases. NF-kappa B signaling pathway plays a significant role in the pathophysiological mechanisms of SCI including increase in inflammation, augmentation of damage caused by free radicals and lipid peroxidation as well as facilitation of apoptosis and axonal demyelination. We also discuss mechanisms between resveratrol and NF-kappa B signaling pathway in the wake of SCI, which can be potential targets for resveratrol to treat SCI.