文献类型：期刊文献

英文题名：Improved physicochemical stability of fish oil nanoemulsion via a dense interfacial layer formed by hyaluronic acid-poly(glyceryl)10-stearate

作者：Ao, Sha[1,2];Luo, Xiang[1,2];Wu, Hongze[1,2];Zhou, Yanyan[1];Yang, Qun[3];Yin, Xuguang[1];Fu, Hongliang[1];Huang, Mengyu[2];Lu, Dandan[2];Zhu, Kewu[1]

机构：[1]Shaoxing Univ, Ctr Drug Delivery Syst Res, Sch Med, 900 Chengnan Ave, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Sch Chem & Chem Engn, 900 Chengnan Ave, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Yuanpei Coll, Sch Med & Hlth, 2799 Qunxian Middle Rd, Shaoxing 312000, Zhejiang, Peoples R China

年份：2024

卷号：444

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001182032900001)、、EI(收录号：20240715544769)、Scopus(收录号：2-s2.0-85184666079)、WOS

基金：We acknowledge the financial support by the General Scientific Research Projects of Zhejiang Provincial Department of Education (No. Y202145959) , the Applied Technology Research and Development Plan Project of Heilongjiang Province (No. GA19C105) , as well as Science and Technology Innovation Activity Plan for College Student in Zhejiang Province & XinMiao Talents Program (Grant No. 2022R432A011) .

语种：英文

外文关键词：Hyaluronic acid; Poly(glyceryl); Nanoemulsions; Surface density; Freeze-thaw stability

外文摘要：This study aimed to synthesize a novel emulsifier, hyaluronic acid-poly(glyceryl)10-stearate (HA-PG10-C18), and employ it for the fabrication of nanoemulsions incorporating deep-sea fish oil to improve their apparent solubility and physicochemical stability. 1H NMR and FT-IR analyses indicated successful synthesis of HA-PG10-C18. Nanoemulsions of deep-sea fish oil loaded with HA-PG10-C18 (HA-PG10-C18@NE) were successfully fabricated by ultrasonic emulsification. The fixed aqueous layer thickness (FALT) of PG10-C18@NE and HA-PG10-C18@NE was determined and the FALT of both nanoemulsions was similar, while the surface density of HA-PG10C18@NE (4.92 x 10-12 ng/nm2) is 60 % higher than that of PG10-C18@NE (3.07 x 10-12 ng/nm2). Notably, HA-PG10-C18@NE demonstrated an exceptional physicochemical stability when exposed to various stressed environmental conditions, especially its freeze-thaw stability. Moreover, after simulated in vitro digestion, the HA-PG10-C18@NE exhibited a comparatively greater liberation of free fatty acids (94.0 +/- 1.7 %) when compared to the release observed in PG10-C18@NE (85.5 +/- 2.2 %).