文献类型：期刊文献

英文题名：Photo-Responsive Ovalbumin-Loaded MnO2 Nanoparticles for Enhanced T1-Magnetic Resonance Imaging and Immunotherapy of Cancer

作者：Hou, Yike[1]; Huang, Shuqi[1]; Tang, Zhe[1]; Yu, Zhangsen[2]; Iqbal, Muhammad Zubair[1]; Kong, Xiangdong[1]

机构：[1] Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; [2] Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Zhejiang, Shaoxing, 312000, China

年份：2024

卷号：41

期号：1

外文期刊名：Particle and Particle Systems Characterization

收录：EI(收录号：20233614663932)、Scopus(收录号：2-s2.0-85169309139)

语种：英文

外文关键词：Antigens - Biocompatibility - Cell culture - Controlled drug delivery - Diagnosis - Diseases - Image enhancement - Irradiation - Mammals - Manganese oxide - Nanomagnetics - Nanoparticles - Oncology - Photodynamic therapy - Targeted drug delivery - Tumors

外文摘要：Photo-responsive combinational therapeutics attained significant attention in cancer theranostic owing to the versatile features of nanomaterials. The simplest nano-design with unique properties to carry out multifunctionalties is a challenging assignment. Herein, a facile solvothermal method is employed to fabricate homogeneous MnO2 sea urchin-shaped nanoparticles?(MnO2-OVA NPs) with a high loading capacity (86.15%) of ovalbumin (OVA) antigen. The prepared MnO2-OVA NPs demonstrated excellent biocompatibility against different cell lines and significant cellular uptake, resulting in mature dendritic cells to enhance anti-tumor immunity. The synthesized sea urchin-shaped MnO2-OVA NPs further exhibited self-generated catalytic properties that efficiently relieve tumor hypoxia and improve cancer therapies. More excitingly, MnO2-OVA NPs endorsed reactive oxygen species (ROS) in response of minute UV irradiation (mW) for photodynamic therapy. Further, the prepared photo-responsive nanoparticles showed promising T1-MR imaging and relaxivity properties for diagnosis and real-time drug delivery monitoring. These synergetic therapeutic strategies produced by MnO2-OVA NPs showed excellency as a potential theranostic agent. ? 2023 Wiley-VCH GmbH.