文献类型：期刊文献

英文题名：SARM1 can be a potential therapeutic target for spinal cord injury

作者：Lu, Qicheng[1];Botchway, Benson O. A.[2];Zhang, Yong[1];Jin, Tian[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Peoples R China;[2]Zhejiang Univ, Sch Med, Inst Neurosci, Hangzhou, Peoples R China

年份：2022

卷号：79

期号：3

外文期刊名：CELLULAR AND MOLECULAR LIFE SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000771055400003)、、Scopus(收录号：2-s2.0-85125427300)、WOS

基金：This work was supported by the Natural Science Foundation of Zhejiang Province (no. LY19H170001).

语种：英文

外文关键词：Sterile alpha and armadillo motif-containing protein 1 (SARM1); Wallerian degeneration; Spinal cord injury; Axonal degeneration; Mitogen-activated protein kinase (MAPK) signaling; Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)

外文摘要：Injury to the spinal cord is devastating. Studies have implicated Wallerian degeneration as the main cause of axonal destruction in the wake of spinal cord injury. Therefore, the suppression of Wallerian degeneration could be beneficial for spinal cord injury treatment. Sterile alpha and armadillo motif-containing protein 1 (SARM1) is a key modulator of Wallerian degeneration, and its impediment can improve spinal cord injury to a significant degree. In this report, we analyze the various signaling domains of SARM1, the recent findings on Wallerian degeneration and its relation to axonal insults, as well as its connection to SARM1, the mitogen-activated protein kinase (MAPK) signaling, and the survival factor, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2). We then elaborate on the possible role of SARM1 in spinal cord injury and explicate how its obstruction could potentially alleviate the injury.