文献类型：期刊文献

英文题名：Mathematical modeling for intracellular transport and binding of HIV-1 Gag proteins

作者：Wang, Yuanbin[1,2];Tan, Jinying[3];Sadre-Marandi, Farrah[4];Liu, Jiangguo[4];Zou, Xiufen[1]

机构：[1]Wuhan Univ, Sch Math & Stat, Wuhan 430072, Peoples R China;[2]Shaoxing Univ, Dept Math, Shaoxing 312000, Peoples R China;[3]Huazhong Agr Univ, Coll Sci, Wuhan 430070, Peoples R China;[4]Colorado State Univ, Dept Math, Ft Collins, CO 80523 USA

年份：2015

卷号：262

起止页码：198

外文期刊名：MATHEMATICAL BIOSCIENCES

收录：SCI-EXPANDED(收录号：WOS:000351962200019)、、EI(收录号：20151400709131)、Scopus(收录号：2-s2.0-84925440953)、WOS

基金：The authors thank the anonymous reviewers for their helpful comments and suggestions. The work of the first, second, and fifth authors was partially supported by the Major Research Plan of the National Natural Science Foundation of China, China (no. 91230118) and the National Natural Science Foundation of China, China (no. 61173060). The third author was partially supported by the US National Science Foundation under grant EAPSI-1415117.

语种：英文

外文关键词：Gag protein; HIV-1; Mathematical modeling; Stability; Monomers; Trimers

外文摘要：This paper presents a modeling study for the intracellular trafficking and trimerization of the HIV-1 Gag proteins. A set of differential equations including initial and boundary conditions is used to characterize the transport, diffusion, association and dissociation of Gag monomers and trimers for the time period from the initial production of Gag protein monomers to the initial appearance of immature HIV-1 virions near the cell membrane (the time duration T-a). The existence and stability of the steady-state solution of the initial boundary value problems provide a quantitative characterization of the tendency and equilibrium of Gag protein movement. The numerical simulation results further demonstrate Gag trimerization near the cell membrane. Our calculations of T-a are in good agreement with published experimental data. Sensitivity analysis of T-a to the model parameters indicates that the timing of the initial appearance of HIV-1 virions on the cell membrane is affected by the diffusion and transport processes. These results provide important information and insight into the Gag protein transport and binding and HIV-1 virion formation. (C) 2015 Elsevier Inc. All rights reserved.