文献类型：期刊文献

英文题名：Sex-related correspondence between mechanical hypersensitivity and the discharge of medullary pain control neurons in neuropathic rats

作者：Wei, Hong[1];Chen, Zuyue[1,2];Lei, Jing[1,3];You, Hao-Jun[3];Pertovaara, Antti[1]

机构：[1]Univ Helsinki, Fac Med, Dept Physiol, Helsinki, Finland;[2]Shaoxing Univ, Sch Med, Dept Med Imaging, Shaoxing, Peoples R China;[3]Yanan Univ, Ctr Translat Med Res Sensory Motor Dis, Yanan, Peoples R China

年份：2023

卷号：813

外文期刊名：NEUROSCIENCE LETTERS

收录：SCI-EXPANDED(收录号：WOS:001065517400001)、、Scopus(收录号：2-s2.0-85167624307)、WOS

语种：英文

外文关键词：Descending pain control; Neuropathic pain; Dorsal reticular nucleus of the medulla; Rostral ventromedial medulla; Sexual dimorphism

外文摘要：Here we studied whether the sex-related difference in mechanical hypersensitivity induced by neuropathy is associated with the discharge rate of medullary pain control neurons. We performed experiments in male and female rats with spared nerve injury (SNI) model of peripheral neuropathy. Mechanical hypersensitivity was assessed behaviorally by monofilaments. Discharge rates of pain-control neurons were determined using in vivo single unit recordings under light anesthesia. Recording targets were two medullary nuclei involved in descending pain control: the rostral ventromedial medulla (RVM) and the medullary dorsal reticular nucleus (DRt). Based on the response to peripheral noxious stimulus, neurons were classified as pronociceptive RVM ON -like or DRt neurons, or antinociceptive RVM OFF-like neurons. Behavioral results indicated that the mechanical hypersensitivity induced by SNI was significantly stronger in females than males. The ongoing discharge rates of pronociceptive RVM ON-like neurons were higher and those of antinociceptive RVM OFF-like neurons lower in SNI females than SNI males. Ongoing discharge rates of pronociceptive DRt neurons were not significantly different between SNI females and males. The results suggest that a sex difference in the discharge rate of pain control neurons in the RVM but not DRt may contribute to the maintenance of stronger neuropathic hyper-sensitivity in females.