文献类型：期刊文献

英文题名：Preparation and drug release property of tanshinone IIA loaded chitosan-montmorillonite microspheres

作者：Luo, Chao[1,2];Yang, Qun[2];Lin, Xinyu[2];Qi, Chenze[3];Li, Guohua[1]

机构：[1]Zhejiang Univ Technol, Coll Chem Engn, 18 Chaowang Rd, Hangzhou 310014, Zhejiang, Peoples R China;[2]Shaoxing Univ, Yuanpei Coll, Dept Med & Hlth, Shaoxing 312000, Peoples R China;[3]Shaoxing Univ, Coll Chem & Chem Engn, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Shaoxing 312000, Peoples R China

年份：2019

卷号：125

起止页码：721

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000458222000079)、、Scopus(收录号：2-s2.0-85058483969)、WOS

基金：The authors acknowledge the financial support from the Natural Science Foundation of Zhejiang province (grant number: LQ16H310002).

语种：英文

外文关键词：Chitosan; Montmorillonite; Composite microspheres; Tanshinone IIA; Drug release

外文摘要：In this study, a biocompatible chitosan/montmorillonite (CS/MMT) composite microsphere was developed as a carrier for loading and sustained-release of the hydrophobic drug of tanshinone IIA. Though the compatibility between hydrophobic drugs and hydrophilic matrix was fairly poor, tanshinone IIA was successfully loaded on the microsphere by the solvent exchange process during chitosan matrix dehydration. The microstructure of the resulting microspheres was characterized with several techniques, such as X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscope (SEM). The results of drug loading and in vitro release study of the tanshinone IIA loaded CS/MMT composite microspheres showed that the incorporation of MMT into CS matrix would enhance the drug encapsulation and retard drug migration. The sample with mass ratio of CS: MMT (10:2) exhibited highest encapsulation efficiency (48.18% +/- 2.54%) and slowest continuous cumulative release of drug in phosphate buffer solution (pH 7.4). It was found that the tanshinone IIA release kinetics fit the Higuchi model and the release mechanism was nonFickian diffusion. Cell viability studies by CCK-8 assay showed that the microspheres showed no obvious cytotoxicity at the dosages below 80 mu g/ml, and the MMT content had no significant effect on cell viability. This work provided a successful method of incorporating hydrophobic drugs into hydrophilic matrices, and has been successfully applied to the preparation of effective and biocompatible drug delivery for tanshinone IIA, (C) 2018 Elsevier B.V. All rights reserved.