文献类型：期刊文献

英文题名：Diffusion and binding of 5-fluorouracil in non-ionic hydrogels with interpolymer complexation

作者：Zhou, Wenbin[1];Lu, Ping[1];Sun, Li[1,2];Ji, Changzhu[1];Dong, Jian[1]

机构：[1]Shaoxing Univ, Sch Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Ningbo Univ, Fac Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China

年份：2012

卷号：431

期号：1-2

起止页码：53

外文期刊名：INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录：SCI-EXPANDED(收录号：WOS:000304246700008)、、Scopus(收录号：2-s2.0-84861329766)、WOS

基金：This work was supported by the National Natural Science Foundation of China (no. 20974063), Natural Science Foundation of Zhejiang Province (nos. Y12E030010 and Y4090504), and Department of Science and Technology of Zhejiang Province (no. 2009R10040).

语种：英文

外文关键词：Hydrogel; Interpenetrating polymer network; Controlled release; Permeation; 5-Fluorouracil

外文摘要：Hydrogen-bonded interpolymer complexes can be used for development of novel dosage forms. In this study, two types of crosslinked hydrogels, copolymer networks of N-vinyl pyrrolidone and acrylamide (PVP-co-PAM) and interpenetrating polymer networks (IPN) composed of crosslinked PVP-co-PAM and poly(vinyl alcohol) (PVA), were synthesized at three different degrees of crosslinking. The side chain groups in such polymers can form non-ionic complexes through H-bonding, resulting in additional "crosslinks" in the hydrogels. Both kinds of hydrogels have significantly larger swelling sensitivities than the networks formed with ionizable side chains. In the IPNs, introduction of the PVA chains into the PVP-co-PAM networks raises the permeability, indicating more open pores. The permeability decreases with the increasing degree of crosslinking of the copolymer. For probing the drug binding in the hydrogels, Fourier transform infrared spectra (FTIR) difference spectroscopy indicated the presence of significant H-bonding interactions between 5-fluorouracil (5-FU) and the side chains of the polymers. Such interactions are larger in the PVP-co-PAM copolymers than in the IPN hydrogels, thereby causing an additional source of the slower release kinetics in the copolymer hydrogels as revealed by the Peppas model, albeit both types of the networks followed a non-Fickian transport mechanism. (C) 2012 Elsevier B.V. All rights reserved.