文献类型：期刊文献

英文题名：Expression of microRNA-155 in circulating T cells is an indicator of immune activation levels in HIV-1 infected patients

作者：Zhang, Zhenghao[1];Wu, Yong[2];Chen, Jiangnan[1];Hu, Fangqing[2];Chen, Xuefang[1];Xu, Wenfang[1]

机构：[1]Shaoxing Univ, Clin Lab, Affiliated Hosp, Shaoxing, Peoples R China;[2]Shaoxing Univ, Dept Gastroenterol, Affiliated Hosp, Shaoxing, Peoples R China

年份：2021

卷号：22

期号：3

起止页码：71

外文期刊名：HIV RESEARCH & CLINICAL PRACTICE

收录：SCI-EXPANDED(收录号：WOS:000681125100001)、、Scopus(收录号：2-s2.0-85112652078)、WOS

基金：This work was supported by the Zhejiang Provincial Science &Technology Foundation(2017KY667) in the collection, analysis and in the decision to submit the article for publication.

语种：英文

外文关键词：Human immunodeficiency virus; combination antiretroviral therapy; microRNA-155; CD38; immune activation

外文摘要：Objectives: MicroRNA-155 (miR-155) regulates activation of T cells. However, its relationship with T-cell immune activation level in human immunodeficiency virus (HIV) patients remains unclear. Methods: We recruited 103 HIV-1 infected patients with combination antiretroviral therapy (cART) and 79 cART naive patients. The miR-155 levels in circulatory T cells were detected by quantitative reverse transcription-PCR. T cell immune activation was detected by the expression of CD38 via flow cytometry. Results: The levels of miR-155 in the total peripheral blood mononuclear cells, CD4+, and CD8+ T cells from HIV-1 patients were increased (p < 0.01). cART naive patients exhibited much higher miR-155 levels in CD4 + and CD8+ T cells than patients with cART(p < 0.01). The percentage of CD4 + CD38+ T and CD8 + CD38+ T cells was also increased in cART naive patients (p < 0.01). MiR-155 level was positively related to immune activation of T cells. Conclusion: Our findings suggest that miR-155 levels in circulating T cells of HIV-1 patients are increased and associated with T cell activation.