文献类型：期刊文献

英文题名：MicroRNA-146a Protects Against Ischemia/Reperfusion Liver Injury Through Inhibition of Toll-like Receptor 4 Signaling Pathway in Rats

作者：Yan Chungen[1];Zhu Dongfang[2];Xia Guoyuan[3]

机构：[1]Shaoxing Univ, Affiliated Hosp, Dept Gastroenterol, Zhongxing South Rd 999, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Affiliated Hosp, Dept Lab Med, Shaoxing, Zhejiang, Peoples R China;[3]Shaoxing Univ, Affiliated Hosp, Dept Ultrasound Diag, Shaoxing, Zhejiang, Peoples R China

年份：2020

卷号：52

期号：3

起止页码：1007

外文期刊名：TRANSPLANTATION PROCEEDINGS

收录：SCI-EXPANDED(收录号：WOS:000523335600049)、、Scopus(收录号：2-s2.0-85080975390)、WOS

基金：The study was supported by Zhejiang Provincial Natural Science Foundation of China (LY15H180008), Zhejiang Provincial Medical Health Science and Technology Project (2019ky726), and Shaoxing Science and Technology Project (2015014001).

语种：英文

外文摘要：Hepatic ischemia/reperfusion injury (IRI) is a severe and common clinical challenge involved in liver surgery and transplantation. MicroRNA-146a (miR-146a) has recently been reported to be abnormally expressed in hepatic IRI, but the underlying mechanism is not fully elucidated. Accumulating evidences showed miR-146a targets Toll-like receptor 4 (TLR4) signaling pathway. Here, we found that miR-146a inhibited TLR4 signaling pathway accompanied by attenuated liver dysfunction, histologic injury and inflammation. Conversely, miR-146a inhibition increased TLR4 and interleukin-1 receptor-associated kinase, accompanied by exacerbated hepatic IRI and inflammation. Taken together, these data indicated that miR-146a protect against hepatic IRI via inhibiting TLR4 signaling pathway. In addition, we verified ultrasound microbubble-mediated gene transfection improved miR-146a transfection efficacy.