文献类型：期刊文献

英文题名：Hollow mesoporous Prussian blue nanozymes alleviate doxorubicin-induced cardiotoxicity by restraining oxidative stress associated with Nrf2 signaling

作者：Wang, Fang[1];Wang, Ke[2,3];Fang, Baoru[2,3];Geng, Siqi[2,3];Li, Ying[2];Qian, Huifeng[4];Lin, Yinuo[1];Yu, Zhangsen[2]

机构：[1]Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Med Sci Res Ctr, Sch Med, Lab Nanomed, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Sch Life & Environm Sci, Shaoxing 312000, Zhejiang, Peoples R China;[4]Shaoxing Second Hosp, Dept Clin Lab, Shaoxing 312000, Zhejiang, Peoples R China

年份：2025

卷号：686

起止页码：1074

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：SCI-EXPANDED(收录号：WOS:001426106700001)、、EI(收录号：20250617840306)、Scopus(收录号：2-s2.0-85217078195)、WOS

基金：This work was financially supported by the project of Zhejiang Provincial Natural Science Foundation (LTGY23H020002, LTGY24H030003) , the Science and Technology Plan in Shaoxing City (2022A14026) , the Medical and Health Science and Technology Plan Project of Zhejiang Province (2024KY495) , Medical and Health Science and Technology Plan Project of Shaoxing (2022KY075) .

语种：英文

外文关键词：Doxorubicin; Hollow mesoporous Prussian blue (HmPB); HmPB(DOX); Doxorubicin-induced cardiotoxicity; Oxidative stress; Reactive oxygen species

外文摘要：Doxorubicin-induced cardiomyopathy (DIC) is a toxic side effect that cannot be ignored during chemotherapy for malignant tumors. In this work, we synthesized a novel nano-chemotherapeutic drug based on Prussian blue nanozyme to alleviate DIC. Hollow mesoporous Prussian blue (HmPB) nanoparticles were used as a carrier to load doxorubicin (DOX) through electrostatic adsorption and obtain a novel chemotherapy drug, HmPB(DOX). In vivo and in vitro chemotherapy efficacy and acute toxicity evaluation experiments were conducted. The results suggest that HmPB(DOX) exhibits pH-responsive characteristics and minimizes the release of DOX from within HmPB(DOX) in cardiomyocytes. However, in the acidic tumor microenvironment, the release of DOX from HmPB (DOX) is notably enhanced. More importantly, HmPB(DOX) possesses excellent antioxidant enzyme activity, effectively clearing DOX-induced reactive oxygen species (ROS) and alleviating oxidative stress in cardiomyocytes. Doxorubicin is pivotal in the chemotherapy of malignant tumors. This study presents novel insights for mitigating the toxic and side effects of DOX, offering new strategies to enhance tolerance to chemotherapy.