文献类型：期刊文献

中文题名：亚慢性钐暴露对小鼠睾丸组织的影响

英文题名：Effects of Subchronic Samarium Exposure on Testicle Tissue of Mice

作者：干雅平[1];申秀英[1];许晓路[2];陈永益[1]

机构：[1]浙江师范大学化学与生命科学学院;[2]绍兴文理学院生物系

年份：2006

卷号：24

期号：2

起止页码：254

中文期刊名：中国稀土学报

外文期刊名：Journal of the Chinese Rare Earth Society

收录：CSTPCD、、北大核心2004、Scopus、CSCD2011_2012、北大核心、CSCD

基金：浙江省分析测试基金(02082);浙江省教育厅(20020853)资助项目

语种：中文

中文关键词：钐;小鼠;睾丸;生化指标;组织病理学;稀土

外文关键词：samarium; mice; testis; biochemical index; histopathology; rare earths

中文摘要：为了探讨稀土元素钐对雄性小鼠睾丸的毒性作用,让5组小鼠自由饮用含硝酸钐0,5,50,500,2000mg·L-1的溶液3个月后,观察钐对睾丸组织生化指标及组织病理学的影响。结果表明,各处理组睾丸结构遭到不同程度的破坏,尤其是精子和间质细胞大量减少。2000mg·L-1剂量组乳酸脱氢酶(LDH)活力和500,2000mg·L-1剂量组乳酸脱氢酶X(LDH-X)活力均受到明显抑制;50,500,2000mg·L-1剂量组山梨醇脱氢酶(SDH)活力明显下降,而γ-谷氨酰基转移酶(γ-GT)活力不受影响;随钐浓度的增加,Na+K+-ATPase,Mg2+-ATPase活力有“低促高抑”的趋势,Ca2+-ATPase活力则均呈抑制作用。说明亚慢性钐暴露对小鼠生殖性腺具有一定的毒性作用。

外文摘要：To study the toxicity of samarium nitrate on male mice＇s testicle tissue, samarium nitrate was administrated to mice at different doses（0, 5, 50, 500, 2000 mg·L^-1） for 3 months. The biochemical index and pathological changes were observed. The results show that the construction of testicle, especially in sperms and testis intersitium are broken. LDH enzyme activity in 21300 mg·L^-1 and LDH-X enzyme activity in 500 and 2000 mg·L^-1 dose groups are inhibited significantly. SDH enzyme activity in 50, 500 and 2000 mg·L^-1 dose groups are lower than that in control group, but 7-GT enzyme activity is unacted on Sin. With increase of samarium concentration, Na^＋ K^＋ -ATP, Mg^2＋ -ATP enzyme activity tend to ＂promote weakly and inhibited strongly＂, while Ca^2＋ -ATPase decrease largely. Subchmnic samarium exposure has definite toxicity to gonad of mice.