文献类型：期刊文献

英文题名：Resveratrol treatment of spinal cord injury in rat model

作者：Liu, Xuehong[1];Botchway, Benson O. A.[2];Tan, Xiaoning[2];Zhang, Yong[1];Fang, Marong[2]

机构：[1]Shaoxing Univ, Dept Histol & Embryol, Sch Med, Shaoxing, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

年份：2019

卷号：82

期号：3

起止页码：296

外文期刊名：MICROSCOPY RESEARCH AND TECHNIQUE

收录：SCI-EXPANDED(收录号：WOS:000459517900014)、、EI(收录号：20232414238781)、Scopus(收录号：2-s2.0-85058950991)、WOS

基金：National Natural Science Foundation of China, Grant/Award Numbers: 81671138, LY15H170001; Public Technology Applied Research Projects Foundation of Shaoxing City, Grant/Award Numbers: 2015B70040 and 2017B70066, 2017B70066, 2015B70040; Zhejiang Provincial Natural Science Foundation of China, Grant/Award Number: LY15H170001; Zhejiang Provincial Natural Science Foundation

语种：英文

外文关键词：electron microscope; immunohistochemistry; resveratrol; spinal cord injury

外文摘要：Spinal cord injury (SCI) is catastrophic and can culminate in disability and death. The routine therapy employed in early stages of SCI currently entails surgical procedures combined with high doses of methylprednisolone (MP). MP is highly controversial for the lack of consensus on its true therapeutic effects. Resveratrol (RES) has recently been recognized as a potential and novel therapeutic drug in SCI. Herein, we investigated the effect of RES in a SCI rat-model and found significant improvement in Basso-Beattie-Bresnahan scores. Results obtained from histological, immunohistochemistry, and ultra-structural examinations evidenced the tremendous treatment effect of RES. On the basis of our experimental results, we hypothesize that RES could serve as an effective SCI therapeutic with prolong treatment time following injury.