文献类型：期刊文献

英文题名：Assembly of 5H-dibenzo[a,d]cycloheptenes by a formal [5+2] annulation of ortho-aryl alkynyl benzyl alcohols with arenes

作者：Zhang, Zhebing[1];Cai, Tao[1,2,3];Zhan, Zhaohui[1];Xu, Huiting[1];Yu, Lemao[1];Luo, Xiang[1];Li, Chunmei[1];Gao, Yuzhen[4];Wei, Xuemei[1];Chen, Xinzhi[3];Shen, Runpu[1,2]

机构：[1]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Zhejiang Engn Res Ctr Fat Soluble Vitamin, Shaoxing, Zhejiang, Peoples R China;[3]Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China;[4]Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China

年份：2022

卷号：20

期号：36

起止页码：7221

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000848884100001)、、EI(收录号：20224112850131)、Scopus(收录号：2-s2.0-85138458413)、WOS、CCR-EXPANDED(收录号：WOS:000848884100001)

基金：T. Cai gratefully acknowledge the financial support from the Zhejiang Provincial Natural Science Foundation of China (No. LQ21B020005).

语种：英文

外文摘要：A new synthetic methodology for the synthesis of 5H-dibenzo[a,d]cycloheptenes from ortho-aryl alkynyl benzyl alcohols and arenes via a Tf2O-mediated formal [5 + 2] annulation reaction has been achieved. From this transformation, structurally diverse 5H-dibenzo[a,d]cycloheptenes were achieved in moderate to good yields. This transformation probably involves an intermolecular Friedel-Crafts-type alkylation and a subsequent intramolecular 7-endo-dig cyclization in one pot, highlighting the high efficiency, regioselectivity, and step-economy of this protocol.