文献类型：期刊文献

英文题名：Visible light mediated sp3 C-H bond functionalization of N-aryl-1,2,3,4-tetrahydroisoquinolines via Ugi-type three-component reaction

作者：Chen, Yunyun[1]; Feng, Gaofeng[1]

机构：[1] Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, 312000, China

年份：2015

卷号：13

期号：14

起止页码：4260

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20151300696314)、Scopus(收录号：2-s2.0-84925703362)

语种：英文

外文关键词：Light - Chlorine compounds

外文摘要：An efficient and high yield process for sp3 C-H bond functionalization of N-aryl-1,2,3,4-tetrahydroisoquinolines is disclosed. This involves a visible light mediated photoredox Ugi-type reaction with carboxylic acids and isonitriles under aerobic conditions, employing Ru(bpy)3Cl2 as a photoredox catalyst and CH3CN as the solvent. CH3CN was found to be crucial for the process, and good to excellent yields were achieved for a wide variety of N-aryl-1,2,3,4-tetrahydroisoquinolines, carboxylic acids, and isonitriles. The developed methodology is attractive for the synthesis of a library of 1,2,3,4-tetrahydroisoquinolines. This journal is ? The Royal Society of Chemistry.