文献类型：期刊文献

中文题名：神经元型一氧化氮合酶和血管内皮生长因子在人胎早期小肠绒毛中的表达及意义

英文题名：Expressions of nNOS and VEGF in the early developing small intestinal villi of human fetus and its significance

作者：刘学红[1];张泳[1];张金萍[1];张剑[1]

机构：[1]绍兴文理学院医学院

年份：2009

期号：5

起止页码：837

中文期刊名：解剖学报

外文期刊名：Acta Anatomica Sinica

收录：CSTPCD、、Scopus、CSCD2011_2012、北大核心2008、北大核心、CSCD

基金：浙江省教育厅科研计划项目研究成果(Y200805569);绍兴文理学院重点资助项目研究成果(08LG1018)

语种：中文

中文关键词：小肠;神经元型一氧化氮合酶;血管内皮生长因子;免疫组织化学;人胎

外文关键词：Small intestine ; Neuronal nitric oxide synthase; Vascular endothelial growth factor;Immunohistochemistry; Human fetus

中文摘要：目的探讨神经元型一氧化氮合酶（nNOS）和血管内皮生长因子（VEGF）在人胎早期小肠绒毛中的表达规律。方法应用免疫组织化学SABC和Pv法检测第2、3、4月龄段，nNOS和VEGF在14例人胎小肠绒毛中的表达。结果第2月胚龄时，nNOS在小肠绒毛中呈阴性表达，VEGF在小肠绒毛上皮细胞呈阳性表达。第3-4月胎龄段，nNOS和VEGF在小肠绒毛部分细胞均呈阳性表达。结论nNOS和VEGF与人胎早期小肠绒毛的生长发育关系密切。

外文摘要：Objective To explore the rule of the expressions of neuronal nitric oxide synthase （nNOS） and vascular endothelial growth factor（VEGF） in the early developing human fetus. Methods At the second to fourth month of gestation, the expressions of nNOS and VEGF were observed in 14 cases of human fetal small intestine villi by using the SABC and PV of the immunohistoehemical methods. Results In the second month of gestation, the expression of nNOS was negative and VEGF was positive at the epithelial cell layer in the small intestinal villi of human fetus. At the third to fourth month of gestation, the expressions of nNOS and VEGF proteins were positive in some cells of the small intestinal villi of human fetus. Conclusion nNOS and VEGF proteins are closely related to the growth and development of the cells and tissues in the early developing small intestinal villi of human fetus.