文献类型：期刊文献

英文题名：Palladium-catalyzed aromatic C-H alkylation of 1-naphthylamines with dichloroalkanes and its application in fused polycyclic amine synthesis

作者：Shi, Yixin[1];Zhou, Ziyi[1];Hu, Yilin[1];Wang, Siyun[1];Hong, Mingzhe[1];Cheng, Kai[1];Jia, Chun-Xiao[3];Wan, Jie-Ping[2,4]

机构：[1]Shaoxing Univ, Inst Appl Chem, Dept Chem, Shaoxing 312000, Peoples R China;[2]Jiangxi Normal Univ, Coll Chem & Mat, Nanchang 330022, Peoples R China;[3]Dezhou Univ, Coll Chem & Chem Engn, Shandong Prov Key Lab Monocrystalline Silicon Semi, Dezhou 253023, Peoples R China;[4]Nanjing Forestry Univ, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China

年份：2025

外文期刊名：CHEMICAL COMMUNICATIONS

收录：SCI-EXPANDED(收录号：WOS:001544614800001)、、EI(收录号：20253519072068)、Scopus(收录号：2-s2.0-105014324508)、WOS

基金：This work is financially supported by the National Natural Science Foundation of China (21402123), and the Natural Science Foundation of Zhejiang Province (LY18B020006).

语种：英文

外文摘要：Herein, we report a palladium-catalyzed aromatic C-H bond alkylation reaction of 1-naphthylamines at the C8 site with dichloroalkanes as alkylating agents. DFT calculation demonstrates the distinctive advantage of the separated dichloroalkanes in the reaction by stabilizing the key intermediate via C-H & ctdot;N or C-H & ctdot;pi interaction induced by the additional Cl atom. In addition to the specific alkylation site selectivity in the naphthyl ring, the products provided by the current C-H alkylation protocol display important applications in the construction of fused polycyclic amines via a one-step treatment.