文献类型：期刊文献

英文题名：Palladium-catalyzed C-3 desulfitative arylation of indolizines with sodium arylsulfinates and arylsulfonyl hydrazides

作者：Wang, Chunjie[1];Jia, Huali[1];Li, Zhiwei[1];Zhang, Hui[1];Zhao, Baoli[2,3]

机构：[1]Zhoukou Normal Univ, Coll Chem & Chem Engn, Zhoukou 466000, Henan Province, Peoples R China;[2]Shaoxing Univ, Inst Appl Chem, Shaoxing 312000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Dept Chem, Shaoxing 312000, Zhejiang, Peoples R China

年份：2016

卷号：6

期号：26

起止页码：21814

外文期刊名：RSC ADVANCES

收录：SCI-EXPANDED(收录号：WOS:000371535200058)、、EI(收录号：20161002050912)、Scopus(收录号：2-s2.0-84959333539)、WOS

基金：This study was supported by the National Natural Science Foundation of China (no. 21402123), the Zhejiang Provincial Natural Science Foundation of China (no. LQ14B020001), and the Education Department of Zhejiang Province (no. Y201328443).

语种：英文

外文关键词：Aromatic compounds - Catalysis - Palladium - Synthesis (chemical)

外文摘要：Derivatized indolizines were efficiently prepared by direct C-3 arylation of indolizines using sodium arylsulfinates and arylsulfonyl hydrazides. Pd-catalyzed desulfitative C-3 arylation with sodium arylsulfinates was achieved with the assistance of peroxides, and the catalytic efficiency was promoted by N-containing ligands. Arylsulfonyl hydrazides were also successfully applied in Pd-catalyzed desulfitative C-3 arylation with indolizines, and the side homocoupling reactions can be restrained in the component solvent under milder conditions. Various derivatives were synthesized in good yields by both methods, offering expedient protocols for the synthesis of C-3 functionalized indolizine molecules.