文献类型：期刊文献

英文题名：Bioactivity and pharmacological properties of alpha-mangostin from the mangosteen fruit: a review

作者：Chen, Guoqing[1];Li, Yong[1];Wang, Wei[2];Deng, Liping[1,2]

机构：[1]Shaoxing Univ, Dept Chem & Chem Engn, Shaoxing, Peoples R China;[2]Shaoxing Univ, Yuanpei Coll, Shaoxing, Peoples R China

年份：2018

卷号：28

期号：5

起止页码：415

外文期刊名：EXPERT OPINION ON THERAPEUTIC PATENTS

收录：SCI-EXPANDED(收录号：WOS:000430500300005)、、WOS

语种：英文

外文关键词：alpha-Mangostin; biological activities; chemopreventive; pharmacology

外文摘要：Introduction: alpha-Mangostin (alpha-MG) is the most representative xanthone isolated from the pericarp of mangosteen, possessing extensive biological activities and pharmacological properties, considered as an antineoplastic agent, antioxidant, anti-proliferation and induces apoptosis. Areas covered: The bioactivity and pharmacological properties of alpha-MG are being actively investigated by various industrial and academic institutions. The bioactivities of alpha-MG have been summarized in several previous reviews, which were worthy of high compliment. However, recently, many new literatures about the bioactivities of alpha-MG have been further reported from 2016 to 2017. Herein, the activities of alpha-MG are supplemented and summarized in this text. Expert opinion: As previously said, alpha-MG possesses good bioactivities pharmacological properties. More recently, it found that alpha-MG has the effect of maintaining cardiovascular system and gastrointestinal health and controlling free radical oxidation. Furthermore, alpha-MG has more applications in cosmetics, with the effects of anti-aging, anti-wrinkle, acne treatment, maintenance of skin lubrication. The application of alpha-MG in treating rheumatoid arthritis has been disclosed and the MG-loaded self-micro emulsion (MG-SME) was designed to improve its pharmacokinetic deficiencies. As mentioned above, alpha-MG can be a promising drug, also worthy of developing, and further research is crucial for the future application of alpha-MG.