文献类型：期刊文献

中文题名：芳基氟硼酸盐同芳香胺“一锅法”Suzuki-Miyaura反应

英文题名：“One-Pot" Suzuki-Miyaura Reaction with Aryltrifluoroborate Salts from Aromatic Amines

作者：韦珊红[1];王晨[1];王建伟[1];程凯[1]

机构：[1]绍兴文理学院 浙江省精细化学品传统工艺替代技术研究重点实验室

年份：2013

卷号：33

期号：11

起止页码：2402

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：SCI-EXPANDED(收录号：WOS:000328597700017)、CSTPCD、、北大核心2011、Scopus(收录号：2-s2.0-84891365277)、WOS、北大核心、CSCD、CSCD2013_2014

基金：Project supported by the National Natural Science Foundation of China (No. 21202102), the Science Technology Department of Zhejiang Province (No. 2012R10014-15) and the Scienece Technology Project of Shaoxing City (No. 2013014017).

语种：中文

中文关键词：交叉偶联;绿色化学;重氮化合物

外文关键词：cross-coupling green chemistry diazo compounds

中文摘要：研究了一种钯催化的芳香胺通过"一锅法"的Suzuki-Miyaura反应制备联苯类化合物.该反应以水作为溶剂,无需分离重氮盐中间体,直接加入芳基氟硼酸钾、碱和催化剂,即可较高产率地得到偶联产物.反应无需加热和惰性气体保护,具有良好的官能团耐受性,是一种绿色高效的偶联方法.我们通过热力学计算推测了碱的加入对于反应的促进作用.

外文摘要：Palladium-catalyzed ＂one-pot＂ Suzuki-Miyaura reactions of various aromatic amines with aryltrifluoroborate salts have been achieved in good yields under simple aerobic conditions in water without heating. The reported cross-coupling reac-tions are tolerant to the common functional groups regardless of electron-withdrawing or electron donating, making these transformations as attractive alternatives to the traditional cross-coupling approaches. Theoretical calculation shows that the coordination of tert-butoxide can lower the transition state energy by 50 kJ/mol for the transmetalation step.