文献类型：期刊文献

英文题名：Biodegradable poly(glycerin citrate) and its application to controlled release of theophylline

作者：Liu, Shixin[1];Jiang, Man[2];Ye, Sai[1];Xu, Xiaohong[1];Lu, Ping[1];Dong, Jian[1,3]

机构：[1]Shaoxing Univ, Dept Chem, Shaoxing 312000, Peoples R China;[2]Ningbo Univ, Fac Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China;[3]Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

年份：2012

卷号：124

期号：5

起止页码：3633

外文期刊名：JOURNAL OF APPLIED POLYMER SCIENCE

收录：SCI-EXPANDED(收录号：WOS:000300971400014)、、EI(收录号：20121114851637)、Scopus(收录号：2-s2.0-84857996865)、WOS

基金：Contract grant sponsor: National Natural Science Foundation of China; contract grant number: 20974063.; Contract grant sponsor: Department of Science and Technology of Zhejiang Province; contract grant number: 2009R10040.; Contract grant sponsor: Natural Science Foundation of Zhejiang Province; contract grant number: Y4090504.

语种：英文

外文关键词：polyester; citric acid; glycerin; biodegradable; controlled release

外文摘要：This study reports properties of a class of biodegradable polyesters based on citric acid and glycerin, both of which are safe ingredients in food, and their usefulness for drug control release applications. Transparent thin films of poly(glycerin citrate) (PGC) prepared by condensation polymerization were characterized by dynamic mechanical analysis, tensile testing, and FTIR spectroscopy. Depending on the acid-to-glycerin molar ratios, the crosslinked films could have glass transition temperatures varying from 30 to 81 degrees C as shown by dynamic mechanical analysis. The ductile PGC films were more prone to hydrolytic degradation than poly(lactic acid). The controlled release properties of the PGC films were evaluated by a permeation study of an exemplary drug theophylline. The diffusion of theophylline in PGC film follows a Super Case II mechanism, but in PGC film modified with PEG4000, the diffusion follows approximately a Case II mechanism (near zero-order release mechanism). (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012