文献类型：期刊文献

英文题名：Association between hemodynamics, morphology, and rupture risk of intracranial aneurysms: a computational fluid modeling study

作者：Qiu, Tianlun[1];Jin, Guoliang[1];Xing, Haiyan[2];Lu, Haitao[3]

机构：[1]Shaoxing Peoples Hosp, Dept Neurosurg, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shaoxing Univ, Sch Med, Shaoxing, Zhejiang, Peoples R China;[3]Shanghai Xinghua Hosp, Chongming Branch, Dept Neurosurg, Shanghai 202150, Peoples R China

年份：2017

卷号：38

期号：6

起止页码：1009

外文期刊名：NEUROLOGICAL SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000403353900012)、、Scopus(收录号：2-s2.0-85014915879)、WOS

基金：This project was sponsored by Zhejiang provincial science and Technology Department of public welfare technology research social development project: Application study of computing fluid dynamics and morphology in intracranial aneurysm development, rupture and treatment (No. 2014C33SA600012).

语种：英文

外文关键词：Intracranial aneurysms; Wall shear stress; Hemodynamics; Computational fluid dynamics

外文摘要：The objective of the study was to examine the correlations between intracranial aneurysm morphology and wall shear stress (WSS) to identify reliable predictors of rupture risk. Seventy-two intracranial aneurysms (41 ruptured and 31 unruptured) from 63 patients were studied retrospectively. All aneurysms were divided into two categories: narrow (aspect ratio ae1.4) and wide-necked (aspect ratio < 1.4 or neck width ae4 mm). Computational fluid dynamics was used to determine the distribution of WSS, which was analyzed between different morphological groups and between ruptured and unruptured aneurysms. Sections of the walls of clipped aneurysms were stained with hematoxylin-eosin, observed under a microscope, and photographed. Ruptured aneurysms were statistically more likely to have a greater low WSS area ratio (LSAR) (P = 0.001) and higher aneurysms parent WSS ratio (P = 0.026) than unruptured aneurysms. Narrow-necked aneurysms were statistically more likely to have a larger LSAR (P < 0.001) and lower values of MWSS (P < 0.001), mean aneurysm-parent WSS ratio (P < 0.001), HWSS (P = 0.012), and the highest aneurysm-parent WSS ratio (P < 0.001) than wide-necked aneurysms. The aneurysm wall showed two different pathological changes associated with high or low WSS in wide-necked aneurysms. Aneurysm morphology could affect the distribution and magnitude of WSS on the basis of differences in blood flow. Both high and low WSS could contribute to focal wall damage and rupture through different mechanisms associated with each morphological type.