文献类型：期刊文献

英文题名：Therapeutic Potential of Foodborne Indole Derived from Chinese Stinky Tofu in Reducing Intestinal Inflammation and Enhancing Barrier Function to Mitigate Alcoholic Liver Injury

作者：Peng, Qi[1];Zheng, Huajun[1];Quan, Leping[1];Li, Shanshan[1];Huang, Jiaxin[1];Li, Jiachen[1];Xie, Guangfa[2]

机构：[1]Shaoxing Univ, Natl Engn Res Ctr Chinese CRW, Branch Ctr, Sch Life & Environm Sci, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Shuren Univ, Key Lab Pollut Exposure & Hlth Intervent Zhejiang, Coll Biol & Environm Engn, Hangzhou 310015, Peoples R China

年份：2024

卷号：72

期号：39

起止页码：21829

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001318691700001)、、EI(收录号：20244117171774)、Scopus(收录号：2-s2.0-85205604070)、WOS

基金：This work was supported by the Zhejiang Shaoxing Huangjiu Industry Innovation Service Complex-Technological Innovation Project in Zhejiang Province (no. 2023KJ082); Foundation of Public Projects of Zhejiang Province, China (no. LGN22C200008); Program Foundation of Public Projects of Shaoxing city, Zhejiang Province, China (no. 2018C30010); Foundation of Public Projects of Zhejiang Province, China (no. 2017C32101); Shaoxing University Fund (no. 08021066), Shaoxing University Fund (no. 08220102213).

语种：英文

外文关键词：Chinese stinky tofu; indole; AHR receptor; intestinal barrier; ALD; fermented food

外文摘要：Indole, a compound in Chinese stinky tofu (ST), acts as a ligand for the aryl hydrocarbon receptor (AHR). Despite extensive research on prebiotic compounds, indole's specific role in ST remains unexplored. This study used an ethanol gavage method to create an ALD (alcoholic liver disease) mouse model and investigate dietary indole's effects on the intestinal barrier. Our findings indicate that after 6 weeks of being fed ST, the indole present (2 mg/day) robustly activated the intestinal AHR, upregulating its target gene, CYP1A1 (cytochrome P450 1A1 enzyme). This activation significantly reduced intestinal permeability, mitigated alcohol-induced oxidative stress and inflammation, and restored intestinal barrier function. Consequently, the study demonstrates that foodborne indole substantially reduces alcohol absorption and lowers the expression levels of liver inflammation-related factors, thereby slowing the progression of ALD. These results highlight indole's therapeutic potential for treating ALD and its role in developing functional foods.