文献类型：期刊文献

英文题名：Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis

作者：Jin, Tian[1];Zhang, Yong[1];Botchway, Benson O. A.[2,3];Huang, Min[1];Lu, Qicheng[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Zhejiang 312000, Peoples R China;[2]Zhejiang Univ, Inst Neurosci, Sch Med, Hangzhou, Peoples R China;[3]Bupa Cromwell Hosp, London, England

年份：2023

卷号：161

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：SCI-EXPANDED(收录号：WOS:000962469400001)、、Scopus(收录号：2-s2.0-85150776486)、WOS

语种：英文

外文关键词：Sestrin2; protein kinase (AMPK); Silent information regulator 1 (SIRT1); Amyotrophic lateral sclerosis; Neurodegenerative diseases; Adenosine5?-monophosphate (AMP)-activated

外文摘要：Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease with poor prognosis. The intricacies surrounding its pathophysiology could partly account for the lack of effective treatment for ALS. Sestrin2 has been reported to improve metabolic, cardiovascular and neurodegenerative diseases, and is involved in the direct and indirect activation of the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/silent information regulator 1 (SIRT1) axis. Quercetin, as a phytochemical, has considerable biological activities, such as anti-oxidation, anti-inflammation, anti-tumorigenicity, and neuroprotection. Interestingly, quercetin can activate the AMPK/SIRT1 signaling pathway to reduce endoplasmic reticulum stress, and alleviate apoptosis and inflammation. This report examines the molecular relationship between Sestrin2 and AMPK/SIRT1 axis, as well as the main biological functions and research progress of quercetin, together with the correlation between quercetin and Sestrin2/AMPK/SIRT1 axis in neurodegenerative diseases.