文献类型：期刊文献

英文题名：Enhanced multiple vibrational resonances by Na+ and K+ dynamics in a neuron model

作者：Wu, Xing-Xing[1];Yao, Chenggui[1,2];Shuai, Jianwei[1]

机构：[1]Xiamen Univ, Dept Phys, Xiamen 361005, Peoples R China;[2]Shaoxing Univ, Dept Math, Shaoxing 312000, Peoples R China

年份：2015

卷号：5

外文期刊名：SCIENTIFIC REPORTS

收录：SCI-EXPANDED(收录号：WOS:000347804300017)、、WOS

基金：This work was supported by the China National Funds for Distinguished Young Scholars under grant 11125419, the National Natural Science Foundation of China under grant 31370830, and the Fujian Province Funds for Leading Scientist in Universities for Shuai; and supported by the National Natural Science Foundation of China under Grants No. 11205103 and the National Science Foundation for Post-doctoral Scientists of China under Grants No. 0660-K83003 for Yao.

语种：英文

外文摘要：Some neuronal receptors perceive external input in the form of hybrid periodic signals. The signal detection may be based on the mechanism of vibrational resonance, in which a system's response to the low frequency signal can become optimal by an appropriate choice of the vibration amplitude of HFS. The vibrational resonance effect is investigated in a neuron model in which the intra- and extra-cellular potassium and sodium concentrations are allowed to evolve temporally, depending on ion currents, Na+-K+ pumps, glial buffering, and ion diffusion. Our results reveal that, compared to the vibrational resonances in the model with constant ion concentrations, the significantly enhanced vibrational multi-resonances can be observed for the single neuron system where the potassium and sodium ion concentrations vary temporally. Thus, in contradiction to a popular view that ion concentrations dynamics play little role in signal detection, we indicate that the neuron's response to an external subthreshold signal can be largely improved by sodium and potassium dynamics.