文献类型：期刊文献

中文题名：p16、p53、C-erbB-2蛋白在胃癌中的表达及其意义

英文题名：Expression of p16, p53 and C-erbB-2 in Gastric Cancer and its Significance

作者：董来华[1];倪克梁[2];葛建荣[1];马君红[1];茅育蕾[1]

机构：[1]浙江省绍兴文理学院医学院附属医院;[2]上海市北医院

年份：2001

卷号：7

期号：4

起止页码：208

中文期刊名：肿瘤学杂志

外文期刊名：Zhejiang Cancer Journal

收录：CSTPCD

基金：绍兴市医药卫生科技计划项目

语种：中文

中文关键词：p53蛋白;C-erbB-2蛋白;增殖细胞核抗原;免疫组织化学;胃癌

外文关键词：stomach neoplasmas;protein, p16; protein,p53; protein,C-erbB-2;proliferating cell nuclear antigen;immunohistochemistry

中文摘要：[目的]研究p16、p53、C erbB 2蛋白的表达与胃癌临床病理学特征的关系。[方法]应用免疫组织化学方法研究100例胃癌组织中 ,p16、p53、C erbB 2蛋白的表达 ,并进行增殖细胞核抗原 (PCNA)检测。[结果]100例胃癌中p16、p53、C erbB 2的阳性率分别为43 %、56%和50%。p53、C erbB 2阳性表达 ,p16阴性表达的患者预后差 (P值分别<0.01和<0.05) ,p53表达与细胞增殖、病理分型、分化程度有密切关系 ,C erbB 2表达与淋巴结转移、浸润深度相关。[结论]多基因分析比单基因分析更有价值 ,p16、p53、C erbB 2蛋白异常表达及其相互作用在胃癌发生、发展中起重要作用 。

外文摘要：To approach the relationship of p16,p53,C erbB 2 expression with the clinicopathological characteristics of gastric cancer.p16,p53,C erbB 2 and proliferating cell nuclear antigen( PCNA ) expressions of 100 cases of gastric cancer tissues were investigated by immunohistochemical method. Of 100 cases with gastric cancer,positive expression rates of p16,p53 and C erbB 2 were 43%, 56% and 50%,respectively.p53,C erbB 2 positive expression and p16 negative expressions indicated bad prognosis (P<0.01 and<0.05). p53 positive expression was closely related to cell proliferation,pathological types and differential degree .C erbB 2 postive expression was correlated to lymph node metastasis and infiltration degree.The protein expression mentioned above occurred in 83% of gastric cancer,the multiple protein expressioned simultaneously in 47%.[Conclusions] The analysis of multi gene is more valuable than that of single gene.The abnormal expressions of p16,p53 and C erbB 2 and their mutual actions play an important role in gastric carcinogenesis.These protein expressions are effective indicators for prognosis of gastric cancer.