文献类型：期刊文献

英文题名：Synchronous primary gastric diffuse large B-cell lymphoma and multiple lung primary adenocarcinoma with pulmonary cryptococosis: a case report and literature review

作者：Yao, Ke-Lin[1];Yu, Zhong-Qiang[1];Jin, Kai[2];Wu, Jian-Jun[2];Wang, Liang[1]

机构：[1]Shaoxing Univ, Shaoxing Municipal Hosp, Dept Radiol, Affiliated Hosp, 999 Zhongxing South Rd, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Radiol, Hangzhou 310009, Zhejiang, Peoples R China

年份：2024

卷号：24

期号：1

外文期刊名：BMC PULMONARY MEDICINE

收录：SCI-EXPANDED(收录号：WOS:001339846000001)、、Scopus(收录号：2-s2.0-85207632048)、WOS

基金：The authors wish to thank the intervention department team of the second affiliated hospital Zhejiang university school of medicine for their help and collaborations.

语种：英文

外文关键词：Pulmonary cryptococcosis; Stomach; Non-hodgkin's lymphoma (NHL); Lung; Adenocarcinoma; CT

外文摘要：BackgroundThe coexistence of non-Hodgkin's lymphoma of the stomach and multiple primary lung adenocarcinomas with pulmonary cryptococcosis has rarely been reported.Case presentationWe herein present a 75-year-old man who was admitted to our hospital due to hematemesis. Gastroscopy and imaging revealed extensive stomach wall thickening and multiple lung lesions, including nodules and cavernous lesion. The patient was diagnosed with primary diffuse large B-cell lymphoma via gastroscopy and bilateral lung primary adenocarcinoma with cryptococcal infection via percutaneous CT-guided puncture biopsy. He subsequently underwent six cycles of R-CHOP regimen for gastric lymphoma, along with CT-guided radiofrequency ablation for the upper lobe of the right lung primary adenocarcinoma and radioactive particle implantation was performed on the lower lobe of the left lung primary adenocarcinoma, supplemented with antifungal therapy. After a definite diagnosis and systemic treatment, the patient was followed up for twenty-seven months with no tumor recurrence, progression or metastasis.ConclusionTo the best of our knowledge, the complex combination of multiple primary malignancies and pulmonary cryptococcal infection is extremely rare. The diagnosis is been confusing and challenging. CT-guided needle biopsy can help achieve pathological diagnosis, elucidate the type and stage of the tumor, and even change the clinical treatment strategy, which is necessary and beneficial.