文献类型：期刊文献

中文题名：一种噻唑类衍生物的合成及应用研究

英文题名：Synthesis and Application of the Thiazole Derivative

作者：黑延琳[1,2];于绪平[1];金剑炜[1];宋少奇[1];商甜波[2,3];罗艳娟[2,3];潘晓军[1];陈龙[1];徐慧婷[2,3]

机构：[1]浙江医药股份有限公司,浙江绍兴312000;[2]脂溶性维生素浙江省工程研究中心(绍兴文理学院),浙江绍兴312000;[3]浙江绍兴文理学院化学化工学院,浙江绍兴312000

年份：2022

卷号：51

期号：14

起止页码：14

中文期刊名：山东化工

外文期刊名：Shandong Chemical Industry

语种：中文

中文关键词：噻唑;合成;药理活性;阿尔兹海默症

外文关键词：thiazole;synthesis;pharmacological activity;alzheimer’s disease;

中文摘要：噻唑类化合物在抗菌、抗结核、抗癌、抗神经衰退性疾病等方面展现着巨大的用途。以对甲基苯酚为原料,通过取代、重排等过程合成目标化合物2-(4-甲基苯氧甲基)-4-(N-异丁基-N-乙酰基-氨甲基)-噻唑,并通过核磁等表征确认结构。同时,对该化合物的药理活性进行了研究,结果表明其对丁酰胆碱酯酶(BuChE)有较强的抑制活性,为开发新型阿尔兹海默症的治疗药物提供了思路。

外文摘要：Thiazole compounds have shown great uses in antibacterial,anti-tuberculosis,anti-cancer,and anti-neurodegenerative diseases.In this paper,the target compound 2-(4-Methylphenoxymethyl)-4-(N-isobutyl-N-acetyl-aminomethyl)-thiazole was synthesized by p-cresol through substitution,rearrangement and other reactions and the structure was confirmed by NMR.At the same time,the pharmacological activity of the compound was studied,and the results showed that it has a strong inhibitory activity on Bu Ch E,which provides ideas for the development of new therapeutic drugs for AD.