文献类型：期刊文献

英文题名：The New Developments of Cantharidin and Its Analogues

作者：Wang, Guofang[1];Chengkai[1];Wang, Wei[2];Wu, Chunlei[1];Hu, Chunqi[1];Deng, Liping[1,2]

机构：[1]Shaoxing Univ, Dept Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Zhejiang Supor Pharmaceut, Shaoxing 312000, Zhejiang, Peoples R China

年份：2017

卷号：39

期号：4

起止页码：599

外文期刊名：JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN

收录：SCI-EXPANDED(收录号：WOS:000413747800015)、、Scopus(收录号：2-s2.0-85032578815)、WOS

基金：This study was financially supported by Zhejiang Provincial Natural Science Foundation of China under Grant (No. LQ13H300001) and by the National Science Foundation for Young Scholars of China under Grant (No. 81202411). The authors also thank Prof. Yongzhou Hu of Zhejiang University for helping providing experiment facilities.

语种：英文

外文关键词：Canthiridin; Cancer; Toxicity; Inhibition; Analogues; PPs

外文摘要：Canthiridin has significant anti-cancer effects and it is limited to be used due to its toxicity. While cantharidin causes some side effects such as hematochezia and tenesmus, it can efficiently inhibit various tumor cell lines, we must attach importance to it. Several its analogues show similar functions like cantharidin without highly toxicity. In order to utilize cantharidin to treat cancer, some viable methods are found to reduce its side effects. Cantharidin can inhibit the activity of protein phosphatases, new researches for the inhibition of protein phosphatases have been implemented.