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Prognostic values of F-box members in breast cancer: an online database analysis and literature review  ( SCI-EXPANDED收录)   被引量:21

文献类型:期刊文献

英文题名:Prognostic values of F-box members in breast cancer: an online database analysis and literature review

作者:Wang, Xiaochen[1,2];Zhang, Tao[1,4];Zhang, Shizhen[3];Shan, Jinlan[1,2]

机构:[1]Zhejiang Univ, Affiliated Hosp 2, Dept Surg Oncol, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China;[2]Zhejiang Univ, Sch Med,Canc Inst, Prov Key Lab Mol Biol Med Sci,Affiliated Hosp 2, Natl Minist Educ,Key Lab Canc Prevent & Intervent, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China;[3]Zhejiang Univ, Sch Med, Inst Translat Med, Hangzhou 310029, Zhejiang, Peoples R China;[4]Shaoxing Univ, Affiliated Hosp, Dept Oncol, Shaoxing 312000, Zhejiang, Peoples R China

年份:2019

卷号:39

期号:1

外文期刊名:BIOSCIENCE REPORTS

收录:SCI-EXPANDED(收录号:WOS:000456367300029)、、Scopus(收录号:2-s2.0-85059452024)、WOS

语种:英文

外文摘要:Introduction: F-box proteins are the substrate-recognizing subunits of SKP1 (S-phase kinase-associated protein 1)-cullin1-F-box protein (SCF) E3 ligase complexes that play pivotal roles in multiple cellular processes, including cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Dysregulation of F-box proteins may lead to an unbalanced proteolysis of numerous protein substrates, contributing to progression of human malignancies. However, the prognostic values of F-box members, especially at mRNA levels, in breast cancer (BC) are elusive. Methods: An online database, which is constructed based on the gene expression data and survival information downloaded from GEO (http://www.ncbi.nlm.nih.gov/geo/), was used to investigate the prognostic values of 15 members of F-box mRNA expression in BC. Results: We found that higher mRNA expression levels of FBXO1, FBXO31, SKP2, and FBXO5 were significantly associated with worse prognosis for BC patients. While FBXO4 and beta-TrCP1 were found to be correlated to better overall survival (OS). Conclusion: The associated results provide new insights into F-box members in the development and progression of BC. Further researches to explore the F-box protein-targetting reagents for treating BC are needed.

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