文献类型：期刊文献

英文题名：Identification and functional characterization of a sTRAIL gene in mussel Hyriopsis cumingii

作者：Yang, Shoubao[1];Xu, Haisheng[2];Mi, Zhongxiang[1];Han, Jiwei[1];Wei, Min[3]

机构：[1]Shaoxing Univ, Coll Life Sci, Shaoxing 312000, Zhejiang, Peoples R China;[2]Zhejiang Univ, Coll Anim Sci, Hangzhou 310029, Zhejiang, Peoples R China;[3]Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230036, Peoples R China

年份：2013

卷号：402

起止页码：92

外文期刊名：AQUACULTURE

收录：SCI-EXPANDED(收录号：WOS:000320583900014)、、WOS

基金：This work was supported by the China Postdoctoral Science Foundation (20100481431), the Key Scientific Program of Shaoxing City, Zhejiang Province, China (2010A22019) and the Zhejiang Provincial Natural Science Foundation of China (LY12C19010).

语种：英文

外文关键词：Hyriopsis cumingii; Soluble tumor necrosis factor-related apoptosis-inducing ligand; Immune response; Apoptosis; Caspase 3

外文摘要：Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) plays an important role in many biological processes including immune response and cell apoptosis. Here, we identified a soluble TRAIL homolog in a mussel species, Hyriopsis cumingii (designated Hc-sTRAIL), which shows significant structural and functional similarities to mammalian sTRAIL. Real-time PCR analysis shows that mussel TRAIL is ubiquitously expressed in various tissues and involved in the immune response of mussel. Study on its apoptotic effect indicates that Hc-sTRAIL can induce significant apoptosis in NCI-H446 cells and involved the caspase 3 pathway. This study provides new insight into the physiological function of Hc-sTRAIL. (c) 2013 Elsevier B.V. All rights reserved.