详细信息
Palladium-Catalyzed Amino-Sulfonylation of Aryl Iodide Derivatives via the Insertion of Sulfur Dioxide: One-Pot Synthesis of Aryl Primary Sulfonamides with Thiourea Dioxides ( EI收录)
文献类型:期刊文献
英文题名:Palladium-Catalyzed Amino-Sulfonylation of Aryl Iodide Derivatives via the Insertion of Sulfur Dioxide: One-Pot Synthesis of Aryl Primary Sulfonamides with Thiourea Dioxides
作者:Ge, Panyu[1]; Zhou, Ziyi[1]; Tao, Jiahao[1]; Cai, Wei[1]; Wu, Minqin[1]; Shan, Xinggang[2]; Li, Yong[1]; Cheng, Kai[1]
机构:[1] Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, 312000, China; [2] Keyi college of Zhejiang Sci-Tech University, Shaoxing, 312369, China
年份:2023
外文期刊名:Synthesis (Germany)
收录:EI(收录号:20242516291420)、Scopus(收录号:2-s2.0-85196367291)
语种:英文
外文关键词:Amides - Amines - Catalysis - Palladium compounds - Thioureas
外文摘要:A palladium-catalyzed one-pot amino-sulfonylation of aryl iodide derivatives with thiourea dioxide, PdCl2dppf, and one-pot added hydroxylamine-O-sulfonic acid is presented. This amino-sulfonylation gave structure diversity to aryl primary sulfonamides and features good functional group compatibility, mild reaction conditions, excellent regioselectivity, and moderate to good yields. The robustness and potential of this method have also been successfully demonstrated by late-stage elaboration and gram-scale reaction. This approach achieves the divergent construction of the complex core structures that are prevalent in highly valuable natural products such as Sulpiride, Venetoclax, and Furosemide. ? 2024. Thieme. All rights reserved.
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