文献类型：期刊文献

英文题名：Finding the priority and cluster of inflammatory biomarkers for infectious preterm birth: a systematic review

作者：Li, Jiayi[1];Ge, Jianrong[1];Ran, Na[1];Zheng, Changwu[1];Fang, Yumeng[1];Fang, Danna[1];Yang, Qian[2];Ma, Yeling[1]

机构：[1]Shaoxing Univ, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China;[2]Shanghai Inst Biomed & Pharmaceut Technol, Shanghai Engn Res Ctr Reprod Hlth Drug & Devices, NHC Key Lab Reprod Regulat, Shanghai, Peoples R China

年份：2023

卷号：20

期号：1

外文期刊名：JOURNAL OF INFLAMMATION-LONDON

收录：SCI-EXPANDED(收录号：WOS:001032435900001)、、Scopus(收录号：2-s2.0-85165678585)、WOS

语种：英文

外文关键词：Preterm birth; Inflammatory factor; Biomarker; Prioritization; Maternal blood

外文摘要：Infectious preterm birth (PTB) is one of the most important causes of perinatal death. It is difficult to find reliable biomarkers accurate to gestational weeks for infectious PTB prediction clinically. Infectious PTB is found usually accompanied with immune imbalance. Thus, the systematic study to find the priority of inflammatory biomarkers and innovative inflammatory clusters for infectious PTB prediction is urgently needed.This systematic study that focused on the inflammatory clusters and infectious PTB in the PubMed database was analyzed by using the criteria of the Population, Intervention, Comparison, Outcome, and Study design (PICOS) framework according to the recommendations of preferred reporting items for systematic reviews and meta-analysis (PRISMA).The network meta-analyzed results showed that the prioritization of the inflammatory factors for infectious PTB prediction is soluble tumor necrosis factor receptor 2 (sTNFR2) > tumor necrosis factor & alpha; (TNF & alpha;) > interleukin-10 (IL-10) > interleukin-6 (IL-6) > C-reactive protein (CRP) > interleukin-1 & beta; (IL-1 & beta;). Furthermore, the results also indicated that global consideration of multiple inflammatory factors, such as CRP/IL-1 & beta;/IL-6 biomarker cluster in gestational 27-34 weeks, and the tumor necrosis factor/nerve growth factor (TNF/NGF) family during gestational 25-33 weeks, were potential biomarker clusters that specific for infectious PTB prediction.This study systematically pointed out prioritization of the inflammatory factors for infectious PTB prediction. The results also provided evidence that maternal inflammatory clusters can predict infectious PTB occurrence at accurate gestational week. The global consideration of multiple inflammatory factors at accurate gestational age is highlighted.