文献类型：期刊文献

英文题名：Bioaccessibility and safety assessment of trace elements from decoction of ''Zhebawei" herbal medicines by in vitro digestion method

作者：Zhou, Yubo[1];Gao, Xiaozhong[1];Wu, Chunlei[1];Wu, Yibin[1]

机构：[1]Shaoxing Univ, Coll Chem & Chem Engn, Shaoxing 312000, Peoples R China

年份：2014

卷号：28

期号：2

起止页码：173

外文期刊名：JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000335706000011)、、Scopus(收录号：2-s2.0-84898033390)、WOS

基金：This work was supported by the Scientific Research Fund of Zhejiang Education Department (Y201122331).

语种：英文

外文关键词：Zhebawei herbal medicines; Bioaccessibility; Risk assessment; ICP-AES

外文摘要：Studies on in vitro bioaccessibility and safety assessment of 6 elements namely Fe, Zn, Cu, Mn, As and Cd in decoction of eight commonly consumed "Zhebawei" herbal medicines were carried out. The method was based on simulation of human digestion in the gastrointestinal tract. Total content and content in extracts from gastrointestinal phases were analyzed for these elements by inductively coupled plasma atomic emission spectrometer (ICP-AES). In decoction of all 8 herbal medicines, it was found that the total content and bioaccessible concentration of these elements varied considerably among the types of herb, and the total content of each element did not show linearity with their bioaccessible content of the corresponding element. There is no risk of adverse health effects resulting from overdose of Fe, Zn, Cu, and Mn for almost all individuals by ingesting recommended maximum daily dose of these eight herbal medicines. In terms of Cd only Ophitopogin japonicum had higher total concentration and bioaccessible content than the value of suggested limit (5.4 mu g/d). For total As content, only Scrophularia ningpoensis and Corydalis yanhusuo did not meet the safety standard. However, regarding bioaccessible As contents, none of the eight herbal medicines exceeded the value of the daily permissible intake of As (0.12 mg). The risk of toxicity from an element in herbal medicine might be overestimated when the total concentration but not the bioaccessible content is taken into account. In vitro digestion method is rapid, relatively simple and inexpensive, which could be helpful in conducting experiments about safety assessment of an element in herbal medicines. (C) 2014 Elsevier GmbH. All rights reserved.