文献类型：期刊文献

英文题名：Probiotics treatment improves cognitive impairment in patients and animals: A systematic review and meta-analysis

作者：Lv, Tingting[1];Ye, Mengfei[2];Luo, Fangyi[1];Hu, Baiqi[1];Wang, Anzhe[1];Chen, Jiaqi[1];Yan, Junwei[1];He, Ziyi[1];Chen, Feng[1];Qian, Chao[2];Zhang, Jian[1];Liu, Zheng[1,3];Ding, Zhinan[1,3]

机构：[1]Shaoxing Univ, Sci Res Ctr Med Sch, Dept Behav Neurosci, Shaoxing 31200, Zhejiang, Peoples R China;[2]Shaoxing Seventh Peoples Hosp, Dept Psychiat, Shaoxing, Zhejiang, Peoples R China;[3]Shaoxing Univ, Lab Forens Toxicol, Judicial Identificat Ctr, Shaoxing 31200, Zhejiang, Peoples R China

年份：2021

卷号：120

起止页码：159

外文期刊名：NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

收录：SCI-EXPANDED(收录号：WOS:000614283300012)、、Scopus(收录号：2-s2.0-85097476449)、WOS

基金：This work was funded by Public Welfare Technology Applied Research Projects in Zhejiang Province (No. 2016C33191), Zhejiang Medical Health Science and Technology Project (No. 2019KY724, 2020KY332), the Scientific Research Fund of Shaoxing University (No. 20125025), and the National Training Program of Innovation and Entrepreneurship for College Students (No. 2017R10349001). We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

语种：英文

外文关键词：Probiotics; Cognitive function; Therapy; Meta-analysis; Morris water maze test; Novel-object recognition test

外文摘要：The gut-brain axis has received considerable attention in recent years, and the "psychobiotics" concept indicates that probiotics have a potential positive effect on cognitive function. Therefore, the aim of this study was to quantitatively evaluate the influence of probiotics on cognition. We conducted a random-eff ;ects meta-analysis of 7 controlled clinical trials and 11 animals studies to evaluate the eff ;ects of probiotics on cognitive function. Probiotics supplementation enhanced cognitive function in both human (0.24 [0.05-0.42]; I-2 = 0 %) and animal studies (0.90 [0.47-1.34]; I-2 = 74 %). Subgroup analyses indicated that the effects of probiotics on cognitively impaired individuals (0.25 [0.05-0.45]; I-2 = 0 %) were greater than those on healthy ones (0.15 [-0.30 to 0.60]; I-2 = 0 %). Furthermore, compared with a multiple-probiotic supplement, a single strain of probiotics was more effective in humans. The meta-analysis provided some suggestions for probiotics intervention and tended to support a customized approach for different individuals to ameliorate cognitive disorders. Future additional clinical trials are necessary to evaluate therapeutic effect and influencing factors.