文献类型：期刊文献

中文题名：海藻酸盐-壳聚糖复合微/纳米凝胶研究进展

英文题名：Research progress on composite micro/nano-gels prepared from alginate and chitosan

作者：李洁[1];朱红娜[1];周莉莉[1];李建法[1]

机构：[1]绍兴文理学院化学系

年份：2013

期号：2

起止页码：207

中文期刊名：化学研究

外文期刊名：Chemical Research

收录：CSTPCD

基金：浙江省公益性技术应用研究计划(2010C32086);浙江省大学生科技创新项目(2010R426024)

语种：中文

中文关键词：海藻酸盐;壳聚糖;复合微;纳米凝胶;研究进展

外文关键词：alginate; chitosan; composite miero/nano-gel; research progress

中文摘要：综述了海藻酸盐-壳聚糖复合微/纳米凝胶研究进展.指出海藻酸盐与壳聚糖的生物相容性、黏附性和降解性良好,以其为原料制备微/纳米凝胶具有方法简便安全、对药物包载效果好等优点,且与常规尺寸凝胶相比分散性和透过性较好.两者复合制备微/纳米凝胶主要采用一步交联、两步交联、自组装等方法,与单一组分凝胶相比优势明显,在药物输送等领域具有良好的应用前景.

外文摘要：A review is given about the research progress of composite micro/nano-gels prepared from alginate and ehitosan. It is pointed out that alginate and ehitosan have good biocompati- bility, bioadhesiveness and biodegradability. The micro/nano-gels derived from alginate and ehitosan are advantageous with simple and safe preparation methods as well as high encapsula- tion efficiency to drugs and better dispersion and penetration capacities than ordinarily-sized gels. Usually, title composite micro/nano-gels can be prepared from the two kinds of polysac- charides with one-step crosslinking route, two-step crosslinking route and self-assembly route. Resultant composite micro/nano-gels have many advantages than the gels derived from the sole component and may find promising applications in drug delivery.