文献类型：期刊文献

英文题名：Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine

作者：Botchway, Benson O. A.[1,2];Liu, Xuehong[3];Zhou, Yu[3];Fang, Marong[1]

机构：[1]Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Neurol,Sch Med, Hangzhou 310052, Peoples R China;[2]Bupa Cromwell Hosp, Pharm Dept, London SW5 0TU, England;[3]Shaoxing Univ, Med Coll, Dept Histol & Embryol, Shaoxing, Zhejiang, Peoples R China

年份：2023

卷号：21

期号：1

外文期刊名：JOURNAL OF TRANSLATIONAL MEDICINE

收录：SCI-EXPANDED(收录号：WOS:000996034900001)、、Scopus(收录号：2-s2.0-85160240629)、WOS

语种：英文

外文关键词：Neurodegeneration; Trace metal dyshomeostasis; Metallobiology

外文摘要：The current ageing trend of the world population has, in part, accounted for Alzheimer disease (AD) being a public health issue in recent times. Although some progress has been made in clarifying AD-related pathophysiological mechanisms, effective intervention is still elusive. Biometals are indispensable to normal physiological functions of the human body-for example, neurogenesis and metabolism. However, their association with AD remains highly controversial. Copper (Cu) and zinc (Zn) are biometals that have been investigated at great length in relation to neurodegeneration, whereas less attention has been afforded to other trace biometals, such as molybdenum (Mo), and iodine. Given the above context, we reviewed the limited number of studies that have evidenced various effects following the usage of these two biometals in different investigative models of AD. Revisiting these biometals via thorough investigations, along with their biological mechanisms may present a solid foundation for not only the development of effective interventions, but also as diagnostic agents for AD.