文献类型：期刊文献

英文题名：Chinese Yellow Wine and Red Wine Inhibit Matrix Metalloproteinase-2 and Improve Atherosclerotic Plaque in LDL Receptor Knockout Mice

作者：Guo, Hangyuan[1];Liu, Longbin[1];Shi, Yafei[2];Sun, Aijing[3];Xu, Fukang[1];Chi, Jufang[1];Huang, Dilai[3]

机构：[1]Shaoxing Univ, Dept Cardiol, Shaoxing Peoples Hosp, Affiliated Hosp 1, Shaoxing 312000, Zhejiang, Peoples R China;[2]Wenzhou Med Coll, Wenzhou 325000, Zhejiang, Peoples R China;[3]Shaoxing Univ, Dept Pathol, Shaoxing Peoples Hosp, Affiliated Hosp 1, Shaoxing 312000, Zhejiang, Peoples R China

年份：2010

卷号：28

期号：3

起止页码：161

外文期刊名：CARDIOVASCULAR THERAPEUTICS

收录：SCI-EXPANDED(收录号：WOS:000277523300006)、、Scopus(收录号：2-s2.0-77952133678)、WOS

基金：We are grateful to Weiping Zheng, Yufeng Wu, and Wenying Liu for technical assistance. This study was supported by a grant-in-aid for General Scientific Research (No. 2007A23009, No. 2008C33058) from Science and Technology Department of Zhejiang Province and Shaoxing City of China.

语种：英文

外文关键词：Atherosclerosis; Homocysteine; LDL Receptor knockout mice; Matrix metalloproteinase; Yellow wine; rice wine

外文摘要：Our previous study found that Chinese yellow wine could inhibit the production of homocysteine (HCY) induced extracellular matrix metalloproteinase-2 (MMP-2) in the cultured rat vascular smooth muscle cells. Little is known about the relationship between Chinese yellow wine and atherosclerosis or MMP-2 in vivo. Thirty-two LDL Receptor knockout mice on a high-fat and l-methionine diet developed plasma hyperhomocysteinemia and atherosclerosis. They were randomly divided into yellow wine group (n = 8), red wine group (n = 8), ethanol group (n = 8), and control group (n = 8), they were sacrificed after 14 weeks. There were no significant differences with plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in the four groups. Plasma HCY was significantly decreased in the yellow wine group compared to the other three groups (P < 0.01). Yellow wine and red wine groups significantly reduced the atherosclerosis lesion area compared to ethanol and control groups (P < 0.001). However, there was no significant discrepancy between the yellow wine group and red wine group. Compared to the control group and ethanol group, the production of MMP-2 reduced 26.8% and 23.6% in the aortic sinus and the activation of MMP-2 reduced 32.6% and 27.3% in the aortic arch in the yellow wine group; the production of MMP-2 reduced 25.7% and 22.4% in the aortic sinus and the activation of MMP-2 reduced 30.2% and 26.6% in the aortic arch in the red wine group. These results suggest that Chinese yellow wine and red wine can inhibit MMP-2 and improve atherosclerosis, and maybe both Chinese yellow wine and red wine have beneficial effects on cardiovascular disease by inhibiting MMP-2.