文献类型：期刊文献

英文题名：Design and synthesis of a new fluorescent probe for cascade detection of Zn2+ and H2PO4- in water and targeted imaging of living cells

作者：Du, Kui[1,2];Liu, Jian[1];Shen, Runpu[1];Zhang, Pengfei[2]

机构：[1]Shaoxing Univ, Sch Chem & Chem Engn, Shaoxing 312000, Peoples R China;[2]Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

年份：2019

卷号：34

期号：4

起止页码：407

外文期刊名：LUMINESCENCE

收录：SCI-EXPANDED(收录号：WOS:000467485600003)、、WOS

基金：National Natural Science Foundation of China, Grant/Award Number: 21376058

语种：英文

外文关键词：fluorescent probe; in water; Galactose; targeted imaging; Zn2+ and H2PO4-

外文摘要：Design and synthesis of new fluorescence probes with good water-solubility is of great importance to better understanding the significant role of ions which are related to biology and the environment. As important ions, zinc ion (Zn2+) and dihydrogen phosphate ion (H2PO4-) display essential roles in living systems, and quantitative detection of these ions in water is still a challenge. In order to consider the significant role of the galactose moiety in the design of a water-soluble fluorescence sensor, herein, we have developed a novel probe, Gal-AQTF, for the cascade detection of Zn2+ and H2PO4- with excellent selectivity in water. Through the introduction of the galactose moiety onto the sensor AQTF, which has been reported earlier by us, the water-solubility, cell compatibility and targeting ability were enhanced. Gal-AQTF has been successfully applied in the imaging of the living cells of HepG2 and A549, and illustrated good selectivity for the HepG2 cells which overly express the asialoglycoprotein (ASGP) receptor.