文献类型：期刊文献

英文题名：OTULIN Can Improve Spinal Cord Injury by the NF-κB and Wnt/β-Catenin Signaling Pathways

作者：Wang, Qianhui[1];Wang, Lvxia[1];Botchway, Benson O. A.[2,3];Zhang, Yong[1];Huang, Min[1];Liu, Xuehong[1]

机构：[1]Shaoxing Univ, Sch Med, Dept Histol & Embryol, Shaoxing 312000, Zhejiang, Peoples R China;[2]Bupa Cromwell Hosp, London SW5 0TU, England;[3]Univ Nicosia, Med Sch, Dept Basic & Clin Sci, Nicosia, Cyprus

年份：2024

外文期刊名：MOLECULAR NEUROBIOLOGY

收录：SCI-EXPANDED(收录号：WOS:001194924000001)、、Scopus(收录号：2-s2.0-85189155909)、WOS

基金：No Statement Available

语种：英文

外文关键词：OTULIN; Spinal cord injury; The NF-kappa B signaling pathway; The Wnt/beta-catenin signaling pathway; Inflammation

外文摘要：Spinal cord injury (SCI) is a significant health concern, as it presently has no effective treatment in the clinical setting. Inflammation is a key player in the pathophysiological process of SCI, with a number of studies evidencing that the inhibition of the NF-kappa B signaling pathway may impede the inflammatory response and improve SCI. OTULIN, as a de-ubiquitination enzyme, the most notable is its anti-inflammatory effect. OTULIN can inhibit the NF-kappa B signaling pathway to suppress the inflammatory reaction via de-ubiquitination. In addition, OTULIN may promote vascular regeneration through the Wnt/beta-catenin pathway in the wake of SCI. In this review, we analyze the structure and physiological function of OTULIN, along with both NF-kappa B and Wnt/beta-catenin signaling pathways. Furthermore, we examine the significant role of OTULIN in SCI through its impairment of the NF-kappa B signaling pathway, which could open the possibility of it being a novel interventional target for the condition.