文献类型：期刊文献

英文题名：Inhibition of NF-κB signaling pathway by resveratrol improves spinal cord injury

作者：Xu L.[1];Botchway B.O.A.[2];Zhang S.[1];Zhou J.[1];Liu X.[1]

机构：[1]Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, China;[2]Institute of Neuroscience, Zhejiang University, School of Medicine, Hangzhou, China

年份：2018

卷号：12

期号：OCT

外文期刊名：Frontiers in Neuroscience

收录：Scopus(收录号：2-s2.0-85055246174)

基金：The Natural Science Foundation of Zhejiang Province (No. LY15H170001) and the Public Technology Applied Research Projects Foundation of Shaoxing City (No. 2015B70040) supported this work.

语种：英文

外文关键词：Apoptosis; Inflammation; NF-κB signaling pathway; Resveratrol; Spinal cord injury

外文摘要：Spinal cord injury (SCI) can have a significant impact on an individual's life. Herein, we discuss how resveratrol improves SCI by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Evidences show resveratrol suppresses NF-κB signaling pathway to exert its beneficial effects on various diseases. NF-κB signaling pathway plays a significant role in the pathophysiological mechanisms of SCI including increase in inflammation, augmentation of damage caused by free radicals and lipid peroxidation as well as facilitation of apoptosis and axonal demyelination. We also discuss mechanisms between resveratrol and NF-κB signaling pathway in the wake of SCI, which can be potential targets for resveratrol to treat SCI. Copyright ? 2018 Xu, Botchway, Zhang, Zhou and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.